Identification of Schizophrenia Susceptibility Loci in the Urban Taiwanese Population.

: Genomic studies have identified several SNP loci associated with schizophrenia in East Asian populations. Environmental factors, particularly urbanization, play a significant role in schizophrenia development. This study aimed to identify schizophrenia susceptibility loci and characterize their biological functions and molecular pathways in Taiwanese urban Han individuals. : Participants with schizophrenia were recruited from the Taiwan Precision Medicine Initiative at Tri-Service General Hospital. Genotype-phenotype association analysis was performed, with significant variants annotated and analyzed for functional relevance. : A total of 137 schizophrenia patients and 26,129 controls were enrolled. Ten significant variants ( < 1 × 10) and 15 expressed genes were identified, including rs1010840 ( and ), rs11083963 (), rs11619878 (LINC00355 and LINC01052), rs117010638 ( and MIR548AP), rs1170702 (LINC01680 and LINC01720), rs12028521 ( and ), rs12859097 (), rs1556812 (), rs78144262 (LINC00977), and rs9997349 (). These variants and associated genes are involved in immune response, blood pressure regulation, muscle function, and the cytoskeleton. : Identified variants and associated genes suggest a potential genetic predisposition to schizophrenia in the Taiwanese urban Han population, highlighting the importance of potential comorbidities, considering population-specific genetic and environmental interactions.