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厄瓜多尔采集的三种不同石蒜科属植物的生物碱分析及抗胆碱酯酶潜力：Rchb.、Herb. 和 Herb.

Alkaloid Profiling and Anti-Cholinesterase Potential of Three Different Genera of Amaryllidaceae Collected in Ecuador: Rchb., Herb. and Herb.

作者信息

Tallini Luciana R, Acosta León Karen, Chamorro Raúl, Osorio Edison H, Bastida Jaume, Jost Lou, Oleas Nora H

机构信息

Grup de Productes Naturals, Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.

Grupo de Investigación de Productos Naturales y Farmacia, Facultad de Ciencias, Escuela Superior Politécnica del Chimborazo, Panamericana Sur km 1 1/2, Riobamba EC060155, Ecuador.

出版信息

Life (Basel). 2024 Jul 24;14(8):924. doi: 10.3390/life14080924.

DOI:10.3390/life14080924
PMID:39202667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11355869/
Abstract

Ecuador is an important center of biodiversity for the plant subfamily Amaryllidoideae, known for its important bioactive molecules. This study aimed to assess the chemical and biological potential of four different Amaryllidoideae species collected in Ecuador: , , , and . Twenty-six alkaloids were identified in the bulb extracts of these species using GC-MS. The extract of exhibited the greatest structural diversity and contained the highest amounts of alkaloids, particularly lycorine and galanthamine. Only for this species, identification of all the alkaloids belonging to this chemical profile was not possible. Six of them remain unidentified. The potential of these three Amaryllidoideae genera against Alzheimer's disease was then evaluated by measuring their AChE and BuChE inhibitory activity, revealing that and (from Sucumbíos province) showed the best results with IC values of 1.73 ± 0.25 and 30.56 ± 1.56 µg·mL, respectively. Molecular dynamic assays were conducted to characterize the possible interactions that occurs among 2-hydroxyanhydrolycorine and the AChE enzyme, concluded that it is stabilized in the pocket in a similar way to galanthamine. This study expands our understanding of the biodiversity of Amaryllidoideae species from Ecuador, highlighting their potential as source of chemical compounds with pharmaceutical applications.

摘要

厄瓜多尔是植物亚科石蒜科重要的生物多样性中心，以其重要的生物活性分子而闻名。本研究旨在评估在厄瓜多尔采集的四种不同石蒜科物种的化学和生物学潜力：[物种1]、[物种2]、[物种3]和[物种4]。使用气相色谱 - 质谱联用仪在这些物种的鳞茎提取物中鉴定出了26种生物碱。[物种1]的提取物表现出最大的结构多样性，并且含有最高含量的生物碱，特别是石蒜碱和加兰他敏。仅对于该物种，无法鉴定属于该化学特征的所有生物碱。其中六种仍未鉴定出来。然后通过测量它们对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BuChE）的抑制活性，评估了这三个石蒜科属对阿尔茨海默病的潜在作用，结果表明[物种2]和[来自苏孔比奥斯省的物种3]表现出最佳结果，IC值分别为1.73±0.25和30.56±1.56μg·mL。进行了分子动力学分析，以表征2 - 羟基脱水石蒜碱与AChE酶之间可能发生的相互作用，得出结论：它在口袋中的稳定方式与加兰他敏相似。这项研究扩展了我们对厄瓜多尔石蒜科物种生物多样性的理解，突出了它们作为具有药物应用的化合物来源的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff5/11355869/15764e8c401f/life-14-00924-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff5/11355869/fccd510e9d49/life-14-00924-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ff5/11355869/15764e8c401f/life-14-00924-g007.jpg

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