Hogan Ava, Mut Melike
Department of Neuroscience, University of Virginia, Charlottesville, VA 22903, USA.
Department of Neurosurgery, University of Virginia, Charlottesville, VA 22903, USA.
Life (Basel). 2024 Aug 2;14(8):975. doi: 10.3390/life14080975.
Glioma, a diverse group of brain and spinal cord tumors arising from glial cells, is characterized by varying degrees of malignancy, with some types exhibiting highly aggressive behavior, rapid proliferation, and invasive growth patterns, posing significant therapeutic challenges. This review delves into the complex interactions between glioma cells, neurotransmitters, and neurosteroids, emphasizing their potential as therapeutic targets. Key neurotransmitters, like glutamate and gamma-aminobutyric acid (GABA), play crucial roles in glioma growth, invasion, and treatment response. This review examines the involvement of neurosteroids in glioma biology and explores innovative therapeutic strategies targeting these systems. It encompasses the biosynthesis and mechanisms of neurosteroids, interactions between gliomas and neurotransmitters, the spatial distribution of neurosteroid synthesis in gliomas, the role of ion channels, hormonal influences, enzyme modulation, and the neuroimmune system in glioma progression. Additionally, it highlights the potential of neurosteroids to modulate these pathways for therapeutic benefit.
胶质瘤是一组起源于神经胶质细胞的脑和脊髓肿瘤，其特点是恶性程度不同，有些类型表现出高度侵袭性、快速增殖和浸润性生长模式，带来了重大的治疗挑战。本综述深入探讨了胶质瘤细胞、神经递质和神经甾体之间的复杂相互作用，强调了它们作为治疗靶点的潜力。关键神经递质，如谷氨酸和γ-氨基丁酸（GABA），在胶质瘤的生长、侵袭和治疗反应中起关键作用。本综述研究了神经甾体在胶质瘤生物学中的作用，并探索了针对这些系统的创新治疗策略。它涵盖了神经甾体的生物合成和作用机制、胶质瘤与神经递质之间的相互作用、神经甾体合成在胶质瘤中的空间分布、离子通道的作用、激素影响、酶调节以及神经免疫系统在胶质瘤进展中的作用。此外，它还强调了神经甾体调节这些途径以实现治疗益处的潜力。
