Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Key Laboratory of Precision Nutrition and Food Quality, China Agricultural University, Beijing 100193, China.
Molecules. 2024 Aug 10;29(16):3793. doi: 10.3390/molecules29163793.
Photodynamic therapy (PDT) is an effective method for treating microbial infections by leveraging the unique photophysical properties of photosensitizing agents, but issues such as fluorescence quenching and the restricted generation of reactive oxygen species (ROS) under hypoxic conditions still remain. In this study, we successfully synthesized and designed a coumarin-based aggregation-induced emission luminogen (AIEgen), called ICM, that shows a remarkable capacity for type I ROS and type II ROS generation. The O yield of ICM is 0.839. The ROS it produces include hydroxyl radicals (HO) and superoxide anions (O), with highly effective antibacterial properties specifically targeting (a Gram-positive bacterium). Furthermore, ICM enables broad-spectrum fluorescence imaging and exhibits excellent biocompatibility. Consequently, ICM, as a potent type I photosensitizer for eliminating pathogenic microorganisms, represents a promising tool in addressing the threat posed by these pathogens.
光动力疗法（PDT）是一种通过利用光敏剂的独特光物理性质来治疗微生物感染的有效方法，但在缺氧条件下，仍然存在荧光猝灭和限制活性氧（ROS）生成等问题。在本研究中，我们成功合成并设计了一种基于香豆素的聚集诱导发射发光体（AIEgen），称为 ICM，它具有显著的产生 I 型 ROS 和 II 型 ROS 的能力。ICM 的 O 产率为 0.839。它产生的 ROS 包括羟基自由基（HO）和超氧阴离子（O），对（革兰氏阳性菌）具有高效的抗菌特性。此外，ICM 能够进行广谱荧光成像，并且表现出优异的生物相容性。因此，作为一种有效的 I 型光敏剂来消除致病微生物，ICM 是应对这些病原体威胁的一种有前途的工具。
