Mourad Dalia F, Radwan Samah, Hamdy Rana, Elkhashab Dina M, Kamel Mahmoud M, Abdel-Moneim Ahmed S, Kadry Dalia Y
Clinical Pathology Department, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Pediatric Oncology Department, National Cancer Institute, Cairo University, Cairo 12613, Egypt.
Microorganisms. 2024 Aug 16;12(8):1686. doi: 10.3390/microorganisms12081686.
This study aimed to investigate LRTIs in cancer patients, focusing on pathogen distribution, and outcomes based on tumor types and antimicrobial treatments. The study included 110 cancer patients exhibiting symptoms of lower respiratory tract infections (LRTIs), consisting of 67 males and 43 females across a wide age range from under 1 year to over 60 years old. Exclusion of SARS-CoV-2 infection was conducted before admission. In addition to classical microbiological methods, fast-track detection using Multiplex Real-Time PCR was employed, utilizing the FTD-33 test kit. The findings revealed a diverse landscape of infections, notably , and . Parainfluenza 3 and 4 viruses, rhinovirus, influenza A subtype H1N1pdm09, influenza B and C viruses, HCoV-229, HCoV-OC43, and HCoV-HKU1 were infrequently detected. Furthermore, the existence of mixed infection highlighted the complexity of disease conditions in cancer patients. An analysis of antimicrobial treatment highlighted significant variations in fatal outcomes for carbapenem and colistimethate sodium. It was concluded that mixed infections were commonly identified as potential causes of LRTIs among cancer patients, while viral infections were less frequently detected. It underscores the complexity of antimicrobial treatment outcomes.
本研究旨在调查癌症患者的下呼吸道感染（LRTIs），重点关注病原体分布以及基于肿瘤类型和抗菌治疗的结果。该研究纳入了110名出现下呼吸道感染症状的癌症患者，其中包括67名男性和43名女性，年龄范围从1岁以下到60岁以上。入院前排除了严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染。除了经典的微生物学方法外，还采用了使用FTD-33检测试剂盒的多重实时聚合酶链反应（Multiplex Real-Time PCR）快速检测方法。研究结果揭示了感染的多样化情况，特别是 、 和 。副流感病毒3型和4型、鼻病毒、甲型H1N1pdm09流感病毒、乙型和丙型流感病毒、人冠状病毒229（HCoV-229）、人冠状病毒OC43（HCoV-OC43）和人冠状病毒HKU1（HCoV-HKU1）很少被检测到。此外，混合感染的存在凸显了癌症患者疾病状况的复杂性。对抗菌治疗的分析突出了碳青霉烯类和粘菌素甲磺酸钠在致命结局方面的显著差异。研究得出结论，混合感染通常被认为是癌症患者下呼吸道感染的潜在原因，而病毒感染的检测频率较低。这凸显了抗菌治疗结果的复杂性。
