Leonov Georgy, Salikhova Diana, Starodubova Antonina, Vasilyev Andrey, Makhnach Oleg, Fatkhudinov Timur, Goldshtein Dmitry
Federal Research Center of Nutrition, Biotechnology and Food Safety, 109240 Moscow, Russia.
Institute of Molecular and Cellular Medicine, RUDN University, 117198 Moscow, Russia.
Microorganisms. 2024 Aug 22;12(8):1732. doi: 10.3390/microorganisms12081732.
Stroke represents a significant global health burden, with a substantial impact on mortality, morbidity, and long-term disability. The examination of stroke biomarkers, particularly the oral microbiome, offers a promising avenue for advancing our understanding of the factors that contribute to stroke risk and for developing strategies to mitigate that risk. This review highlights the significant correlations between oral diseases, such as periodontitis and caries, and the onset of stroke. Periodontal pathogens within the oral microbiome have been identified as a contributing factor in the exacerbation of risk factors for stroke, including obesity, dyslipidemia, atherosclerosis, hypertension, and endothelial dysfunction. The alteration of the oral microbiome may contribute to these conditions, emphasizing the vital role of oral health in the prevention of cardiovascular disease. The integration of dental and medical health practices represents a promising avenue for enhancing stroke prevention efforts and improving patient outcomes.
中风是一项重大的全球健康负担，对死亡率、发病率和长期残疾有着重大影响。对中风生物标志物，尤其是口腔微生物群的研究，为增进我们对导致中风风险的因素的理解以及制定降低该风险的策略提供了一条很有前景的途径。本综述强调了诸如牙周炎和龋齿等口腔疾病与中风发病之间的显著关联。口腔微生物群中的牙周病原体已被确定为中风风险因素加剧的一个促成因素，这些风险因素包括肥胖、血脂异常、动脉粥样硬化、高血压和内皮功能障碍。口腔微生物群的改变可能导致这些情况，这凸显了口腔健康在预防心血管疾病中的关键作用。牙科和医疗健康实践的整合是加强中风预防工作和改善患者预后的一条很有前景的途径。
