Gao Chuqi, Li Xuantao, Zhao Xiaole, Yang Peiyue, Wang Xiao, Chen Xiaoli, Chen Ning, Chen Feng
Central Laboratory Peking University Hospital of Stomatology Beijing China.
Department of Gastroenterology Peking University People's Hospital Beijing China.
Imeta. 2022 Apr 11;1(2):e19. doi: 10.1002/imt2.19. eCollection 2022 Jun.
The microbiome is in a symbiotic relationship with the host. Among the microbial consortia in the human body, that in the oral cavity is complex. Instead of repeatedly confirming biomarkers of oral and systemic diseases, recent studies have focused on a unified clinical diagnostic standard in microbiology that reduces the heterogeneity caused by individual discrepancies. Research has also been conducted on other topics of greater clinical importance, including bacterial pathogenesis, and the effects of drugs and treatments. In this review, we divide existing research into technology-driven and hypothesis-driven, according to whether there is a clear research hypothesis. This classification allows the demonstration of shifts in the direction of oral microbiology research. Based on the shifts, we suggested that establishing clear hypotheses may be the solution to major research challenges.
微生物群与宿主处于共生关系。在人体的微生物群落中，口腔中的微生物群落很复杂。近期研究不再反复确认口腔疾病和全身性疾病的生物标志物，而是侧重于微生物学中的统一临床诊断标准，以减少个体差异导致的异质性。还开展了关于其他更具临床重要性的主题的研究，包括细菌致病机制以及药物和治疗的效果。在本综述中，我们根据是否有明确的研究假设，将现有研究分为技术驱动型和假设驱动型。这种分类有助于展示口腔微生物学研究方向的转变。基于这些转变，我们认为建立明确的假设可能是应对主要研究挑战的解决方案。
