Cox C F, Bergenholtz G, Heys D R, Syed S A, Fitzgerald M, Heys R J
J Oral Pathol. 1985 Feb;14(2):156-68. doi: 10.1111/j.1600-0714.1985.tb00479.x.
Four adult Rhesus monkeys provided 120 teeth for buccal Class V cavities. Twenty-nine were non-exposed controls and 91 were exposed for 3 intervals. All 120 teeth were capped with a hard set Ca(OH)2 medicament, restored with amalgam, 57 evaluated after 1 year and 63 after 2 years. Of the 91 exposed pulps, 45 showed complete healing, 25 showed pulpal inflammation varying from acute to chronic, 12 showed severe pulpal breakdown and abscess formation and 9 were necrotic. No difference was observed in the healing response between the 3 exposure times. New hard tissue formed at, or subjacent to, the medicament in 77 of 91 exposed pulps with a tunnel defect frequently present, running from the medicament interface to the pulp. This study demonstrates that recurring pulp inflammation observed after 1 & 2 year direct pulp capping, is associated with bacterial contamination.
四只成年恒河猴提供了120颗牙齿用于制备颊侧V类洞。29颗为未暴露牙髓的对照牙，91颗暴露牙髓并分为3个时间段观察。所有120颗牙齿均用硬固化氢氧化钙药物覆盖，用银汞合金修复，1年后评估57颗，2年后评估63颗。在91颗暴露牙髓中，45颗显示完全愈合，25颗显示从急性到慢性的牙髓炎症，12颗显示严重的牙髓破坏和脓肿形成，9颗坏死。在3个暴露时间段之间未观察到愈合反应的差异。91颗暴露牙髓中有77颗在药物处或其下方形成了新的硬组织，经常出现从药物界面到牙髓的隧道状缺损。本研究表明，1年和2年直接盖髓后观察到的复发性牙髓炎症与细菌污染有关。
