Cox C F, Bergenholtz G, Fitzgerald M, Heys D R, Heys R J, Avery J K, Baker J A
J Oral Pathol. 1982 Aug;11(4):327-39. doi: 10.1111/j.1600-0714.1982.tb00173.x.
The healing capacity of mechanically exposed and bacterially contaminated dental pulps was assessed in monkeys after capping with 2 commercial Ca(OH)2 containing compounds. One hundred eighty teeth in 7 monkeys were employed, 45 as untreated controls and 135 as treated exposures. Class V buccal cavity preparations resulting in pulpal exposure were prepared, left open to the oral cavity for 0, 1, 24 h or 7 days and employed as controls, or debrided, capped, restored with amalgam and left undisturbed for 5 weeks as treated exposures. Zero and 1 h untreated exposures presented damage from the mechanical trauma only, whereas 24 h and 7 day pulp wounds exhibited pronounced infiltrations of polymorphonuclear and mononuclear leukocytes. In addition, the 7 day exposures demonstrated several teeth with partial and total necrosis. Treated 0, 1 and 24 h exposures demonstrated wound healing, minimal pulp tissue inflammation, reorganization of soft tissue and formation of new hard tissue at the exposure site in 86 of 99 teeth. Treated 7 day exposures healed less frequently, showing signs of dentin bridging in 15 of 27 teeth. This study indicated that mechanically exposed and orally contaminated dental pulps in monkeys have a high capacity to resolve inflammation and initiate healing with new dentin formation at the exposure site when treated as described.
用两种市售含氢氧化钙的化合物覆盖猴牙后，评估机械暴露且受细菌污染的牙髓的愈合能力。选用7只猴子的180颗牙齿，45颗作为未处理对照，135颗作为处理过的暴露牙。制备导致牙髓暴露的V类颊面洞，分别开放于口腔0、1、24小时或7天作为对照，或进行清创、覆盖、用汞合金修复并保持5周作为处理过的暴露牙。未处理的0小时和1小时暴露牙仅显示机械创伤造成的损伤，而24小时和7天的牙髓创口则有明显的多形核白细胞和单核细胞浸润。此外，7天暴露组的几颗牙齿出现部分和完全坏死。处理过的0、1和24小时暴露牙显示创口愈合，99颗牙齿中有86颗在暴露部位有轻微的牙髓组织炎症、软组织重组和新硬组织形成。处理过的7天暴露牙愈合频率较低，27颗牙齿中有15颗显示有牙本质桥形成迹象。本研究表明，如所述处理时，猴牙机械暴露且受口腔污染的牙髓具有很高的能力来消退炎症，并在暴露部位启动新牙本质形成的愈合过程。
