Takeda Y, Suzuki A, Ishikawa G
J Oral Pathol. 1985 Feb;14(2):182-9. doi: 10.1111/j.1600-0714.1985.tb00481.x.
Multinodular hyperplastic foci of oncocytes found in mouse submandibular glands were examined ultrastructurally, and their morphogenesis discussed. The oncocytic foci showed lobular architecture surrounded by myoepithelial cells, and tubular formations were frequently present. The cytoplasm of the oncocytes was distended by tightly-packed and non-oriented mitochondria which varied in size and shape. Furthermore, varying numbers of electron-dense fine granules, which were remnants of secretory granules of granular duct cells, were scattered in the cytoplasm. Within the salivary gland parenchyma neighboring the hyperplastic foci of oncocytes, intermediate-type cells between oncocytes and normal salivary gland epithelia were found. The result of the present study shows that the oncocytic change has a tendency to be more frequent in the granular ducts and less in the striated ducts, and that some oncocyte-transformed cells proliferate to form nodular hyperplastic foci.
对在小鼠下颌下腺中发现的嗜酸性细胞多结节性增生灶进行了超微结构检查，并对其形态发生进行了讨论。嗜酸性细胞灶呈现出由肌上皮细胞围绕的小叶结构，且经常出现管状结构。嗜酸性细胞的细胞质因紧密排列且无定向的线粒体而扩张，这些线粒体大小和形状各异。此外，不同数量的电子致密细颗粒分散在细胞质中，这些细颗粒是颗粒导管细胞分泌颗粒的残余物。在与嗜酸性细胞增生灶相邻的唾液腺实质内，发现了嗜酸性细胞与正常唾液腺上皮之间的中间型细胞。本研究结果表明，嗜酸性细胞变化在颗粒导管中更频繁，在纹状导管中较少，并且一些嗜酸性细胞转化的细胞增殖形成结节性增生灶。
