Matsuura S, Sahara N, Suzuki K
Cell Tissue Res. 1984;235(2):295-301. doi: 10.1007/BF00217853.
The fine structure of the submandibular gland of the mouse with testicular feminization (Tfm/Y) was studied by light and electron microscopy. The architecture of the Tfm/Y gland proved to be rather similar to that of the normal female mouse in both tubular ratio and structure. Granular convoluted tubular cells in Tfm/Y mice characteristically had fewer secretory granules and increased cytoplasmic vacuoles than normal littermates, suggesting an altered synthesis of secretory granules in this cell type of the Tfm/Y mouse. Moreover, there were differences in the ultrastructure of submandibular glands between Tfm/Y and normal female mice. In the gland of the Tfm/Y mouse, basal striations of the striated secretory tubular cells were not so developed and granular intercalated duct cells were less than those of normal females. These findings support the evidence that the secretory tubule of the mouse submandibular gland responds to androgens, resulting in accentuated development in the male, while also suggesting the possibility that the mouse submandibular gland is regulated by other factors which lead to the prominent sexual dimorphism observed in this gland.
通过光学显微镜和电子显微镜对睾丸雌性化（Tfm/Y）小鼠的下颌下腺精细结构进行了研究。结果表明，Tfm/Y小鼠下颌下腺的结构在小管比例和结构上与正常雌性小鼠颇为相似。与正常同窝小鼠相比，Tfm/Y小鼠的颗粒曲管细胞的分泌颗粒较少，细胞质空泡增多，这表明Tfm/Y小鼠的这种细胞类型中分泌颗粒的合成发生了改变。此外，Tfm/Y小鼠与正常雌性小鼠下颌下腺的超微结构也存在差异。在Tfm/Y小鼠的腺体中，纹状分泌小管细胞的基底横纹发育不那么发达，颗粒间分泌小管细胞比正常雌性小鼠的少。这些发现支持了小鼠下颌下腺分泌小管对雄激素有反应，从而导致雄性下颌下腺发育更显著的证据，同时也表明小鼠下颌下腺可能受其他因素调节，从而导致该腺体出现明显的性别二态性。
