Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
GENYO Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government PTS Granada-Avenida de la Ilustración, 114, 18016 Granada, Spain.
Nutrients. 2024 Aug 10;16(16):2639. doi: 10.3390/nu16162639.
Neurodevelopmental disorders (NDDs) like intellectual disability (ID) are highly heritable, but the environment plays an important role. For example, endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and its analogues, have been termed neuroendocrine disruptors. This study aimed to evaluate the influence of different genetic polymorphisms (SNPs) on cognitive function in Spanish schoolchildren according to dietary bisphenol exposure.
A total of 102 children aged 6-12 years old were included. Ten SNPs in genes involved in brain development, synaptic plasticity, and neurotransmission (, , , , , , and ) were genotyped. Then, dietary exposure to bisphenols (BPA plus BPS) was estimated and cognitive functions were assessed using the WISC-V Spanish form.
rs11030101-T and rs363039-A allele carriers scored better on the fluid reasoning domain, except for those inheriting the rs6265-A allele, who had lower scores. Secondly, relevant SNP-bisphenol interactions existed in verbal comprehension ( rs10868235 (-int = 0.043)), working memory ( rs7997012 (-int = 0.002), rs1801133 (-int = 0.026), and rs53576 (-int = 0.030)) and fluid reasoning ( rs998424 (-int = 0.004)).
Our findings provide the first proof that exploring the synergistic or additive effects between genetic variability and bisphenol exposure on cognitive function could lead to a better understanding of the multifactorial and polygenic aetiology of NDDs.
神经发育障碍（NDD），如智力障碍（ID），具有高度遗传性，但环境也起着重要作用。例如，内分泌干扰化学品（EDCs），包括双酚 A（BPA）及其类似物，被称为神经内分泌干扰物。本研究旨在评估根据儿童饮食中双酚暴露情况，不同基因多态性（SNP）对西班牙学龄儿童认知功能的影响。
共纳入 102 名 6-12 岁儿童。对涉及大脑发育、突触可塑性和神经递质的基因中的 10 个 SNP（ 、 、 、 、 、 、 、 、 ）进行了基因分型。然后，估计了双酚（BPA 和 BPS）的膳食暴露量，并使用 WISC-V 西班牙语版评估了认知功能。
rs11030101-T 和 rs363039-A 等位基因携带者在流体推理域的得分更好，除了遗传 rs6265-A 等位基因的人得分较低。其次，在言语理解方面存在相关 SNP-双酚相互作用（ rs10868235(-int = 0.043)）、工作记忆（ rs7997012(-int = 0.002)、rs1801133(-int = 0.026)和 rs53576(-int = 0.030)）和流体推理（ rs998424(-int = 0.004)）。
我们的研究结果首次证明，探索遗传变异性和双酚暴露对认知功能的协同或累加效应，可能有助于更好地理解 NDD 的多因素和多基因病因。
