Zhang Yu-Xin, Yang Lu-Ping, Gai Cong, Cheng Cui-Cui, Guo Zhen-Yu, Sun Hong-Mei, Hu Die
Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Front Psychiatry. 2022 Aug 18;13:976428. doi: 10.3389/fpsyt.2022.976428. eCollection 2022.
Psychiatric disorders have seriously affected human life, one of the risk genes related to psychosis is the methylenetetrahydrofolatereductase (MTHFR) gene. This gene has a potential role in psychiatric disorders. Therefore, a meta-analysis is conducted to investigate the correlations between two prevalent MTHFR single nucleotide polymorphisms (SNPs), MTHFR C677T, A1298C, severe psychological disorders (schizophrenia, major depression, bipolar disorder).
A total of 81 published studies were screened and selected by a search of electronic databases up to April 2022. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between MTHFR polymorphism and psychiatric disorders susceptibility by using random effect models.
We found that MTHFR C677T polymorphism is significantly related to schizophrenia and major depression in the overall population. MTHFR C677T has been linked to an increased risk of bipolar disorder in the recessive model (TT vs. CT + CC). Ethnic subgroup analysis shows that schizophrenia and major depression significantly correlate with MTHFR C677T and A1298C in Asian populations but not Caucasians. Besides, schizophrenia is correlated substantially with MTHFR C677T in the African population. However, the MTHFR A1298C polymorphism is only marginally linked to major depression.
Findings of the current study revealed that MTHFR may contribute to the common pathogenesis of psychiatric diseases and that its variants may be essential in controlling the expression of psychosis-related genes. This study could help the researchers and health specialists in the early diagnosis and treatment of psychiatric disorders.
精神疾病严重影响人类生活，与精神病相关的风险基因之一是亚甲基四氢叶酸还原酶（MTHFR）基因。该基因在精神疾病中具有潜在作用。因此，进行一项荟萃分析以研究两种常见的MTHFR单核苷酸多态性（SNP），即MTHFR C677T、A1298C与严重心理障碍（精神分裂症、重度抑郁症、双相情感障碍）之间的相关性。
通过检索截至2022年4月的电子数据库，共筛选并选择了81项已发表的研究。采用随机效应模型，以比值比（OR）及95%置信区间（CI）评估MTHFR基因多态性与精神疾病易感性之间的关联。
我们发现，在总体人群中，MTHFR C677T多态性与精神分裂症和重度抑郁症显著相关。在隐性模型（TT与CT + CC相比）中，MTHFR C677T与双相情感障碍风险增加有关。种族亚组分析表明，在亚洲人群中，精神分裂症和重度抑郁症与MTHFR C677T和A1298C显著相关，而在白种人中则不然。此外，在非洲人群中，精神分裂症与MTHFR C677T密切相关。然而，MTHFR A1298C多态性仅与重度抑郁症有微弱关联。
本研究结果表明，MTHFR可能参与精神疾病的共同发病机制，其变异可能对控制精神病相关基因的表达至关重要。本研究可为研究人员和健康专家在精神疾病的早期诊断和治疗方面提供帮助。
