Department of Food and Nutrition, Seoul Women's University, Seoul 01797, Republic of Korea.
Department of Internal Medicine, National Medical Center, Seoul 04564, Republic of Korea.
Nutrients. 2024 Aug 17;16(16):2749. doi: 10.3390/nu16162749.
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic kidney disorder with multiple cyst formation that progresses to chronic kidney disease (CKD) and end-stage kidney disease. Plant-based diets have attracted considerable attention because they may prevent CKD development. This study investigated whether adherence to a plant-based diet is associated with kidney function in patients with ADPKD. The overall plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI) were calculated using dietary intake data. Among 106 ADPKD patients, 37 (34.91%) were classified as having advanced CKD (eGFR < 60 mL/min/1.73 m). The overall PDI and hPDI were lower, but the uPDI was higher in patients with advanced CKD than in those with early CKD. The hPDI was negatively correlated with the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio. Moreover, the hPDI was inversely associated with advanced CKD [odds ratio (OR): 0.117 (95% confidence interval (CI): 0.039-0.351), < 0.001], and the uPDI was positively associated with advanced CKD [OR: 8.450 (95% CI: 2.810-25.409), < 0.001]. The findings of the current study demonstrate that greater adherence to a healthful plant-based diet is associated with improved kidney function in ADPKD patients.
常染色体显性多囊肾病 (ADPKD) 是一种遗传性肾脏疾病，会导致多个囊肿形成，进而发展为慢性肾脏病 (CKD) 和终末期肾病。植物性饮食因其可能预防 CKD 的发生而受到广泛关注。本研究旨在探讨 ADPKD 患者的植物性饮食依从性与肾功能之间的关系。通过饮食摄入数据计算出总体植物性饮食指数 (PDI)、健康 PDI (hPDI) 和不健康 PDI (uPDI)。在 106 例 ADPKD 患者中，37 例 (34.91%) 被归类为患有晚期 CKD (eGFR < 60 mL/min/1.73 m)。与早期 CKD 患者相比，晚期 CKD 患者的总体 PDI 和 hPDI 较低，但 uPDI 较高。hPDI 与中性粒细胞与淋巴细胞比值和血小板与淋巴细胞比值呈负相关。此外，hPDI 与晚期 CKD 呈负相关 (OR：0.117 (95%CI：0.039-0.351)， < 0.001)，而 uPDI 与晚期 CKD 呈正相关 (OR：8.450 (95%CI：2.810-25.409)， < 0.001)。本研究结果表明，ADPKD 患者更依从健康的植物性饮食与改善肾功能相关。
