Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Nutrients. 2024 Aug 17;16(16):2751. doi: 10.3390/nu16162751.
This study aims to compare the cognitive function of women with T1DM during and after pregnancy, as well as one year post-delivery. Additionally, it aims to investigate the impacts of leptin and body mass index on cognitive function.
A prospective longitudinal cohort study was conducted involving 64 pregnant women with T1DM. Cognitive function was assessed using a cognitive assessment battery during the first trimester, immediately after delivery, and one year postpartum for the final assessment. This program evaluates a wide range of cognitive abilities and provides a comprehensive cognitive well-being score (high-moderate-low), identifying strengths and weaknesses in reasoning, memory, attention, coordination, and perception.
The average age of the participants was 30.9 years, with a mean diabetes duration of 14.9 years. Pregnant women with a BMI of 30 kg/m or higher faced an increased risk of reduced cognitive function, memory, and reasoning. Additionally, mothers with lower overall cognitive function and memory levels had significantly higher concentrations of leptin in their blood.
Cognitive functions-particularly reasoning and attention-are adversely affected in women with T1DM during pregnancy and shortly after delivery. Elevated BMI and leptin levels can be linked to worse cognitive outcomes in this population.
本研究旨在比较 T1DM 女性在妊娠期间和产后以及产后一年的认知功能，并探讨瘦素和体重指数对认知功能的影响。
进行了一项前瞻性纵向队列研究，纳入 64 名 T1DM 孕妇。在妊娠早期、分娩后立即和产后一年进行认知评估，最后一次评估使用认知评估工具包进行。该方案评估了广泛的认知能力，并提供了综合认知健康评分（高-中-低），确定了推理、记忆、注意力、协调和感知方面的优势和劣势。
参与者的平均年龄为 30.9 岁，糖尿病病程平均为 14.9 年。BMI 为 30 kg/m2 或更高的孕妇认知功能、记忆力和推理能力下降的风险增加。此外，整体认知功能和记忆水平较低的母亲血液中的瘦素浓度显著更高。
T1DM 女性在妊娠期间和产后不久认知功能受到不良影响，尤其是推理和注意力。较高的 BMI 和瘦素水平与该人群认知结局较差有关。
