尼日利亚埃努古肥胖和非肥胖孕妇足月时血清瘦素水平及其与母体体重增加的关系：一项比较性横断面研究。

Serum leptin levels and relationship with maternal weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria: a comparative cross-sectional study.

机构信息

Department of Obstetrics and Gynaecology, Enugu State University of Science and Technology, College of Medicine/Teaching Hospital, Parklane, Enugu, Nigeria.

Department of Community Medicine, University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Nigeria.

出版信息

J Int Med Res. 2023 Nov;51(11):3000605231213265. doi: 10.1177/03000605231213265.

DOI:10.1177/03000605231213265

PMID:38017364

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10686020/

Abstract

OBJECTIVE

To determine and compare the mean maternal serum leptin levels, the prevalence of high serum leptin levels and mean gestational weight gain at term among obese and non-obese pregnant women in Enugu, Nigeria.

METHODS

This cross-sectional comparative study enrolled obese and non-obese pregnant women. The serum leptin levels of the women were determined using an enzyme-linked immunosorbent assay kit. Anthropometric and sociodemographic data were obtained and compared. Mean weight gain during pregnancy was determined.

RESULTS

A total of 170 pregnant women were included in the study. The mean ± SD serum leptin level (99.39 ± 50.2 ng/ml) and the prevalence of hyperleptinaemia (81 of 85 patients; 95.3%) among the obese pregnant women at term were significantly higher than those of the non-obese pregnant women (48.98 ± 30.35 ng/ml/65 of 85 patients; 76.5%). The mean percentage weight gain was significantly higher in the non-obese women compared with the obese women at term. The predictors of high maternal serum leptin level at term among the participants were the employment status and levels of education of the participants.

CONCLUSION

Maternal serum leptin level, maternal weight gain and prevalence of hyperleptinaemia at term were significantly higher in the obese compared with the non-obese pregnant women.

摘要

目的

在尼日利亚埃努古，确定并比较肥胖和非肥胖孕妇的母体血清瘦素水平平均值、高血清瘦素水平的患病率以及足月时的平均体重增加量。

方法

这是一项横断面对比研究，纳入了肥胖和非肥胖的孕妇。采用酶联免疫吸附测定试剂盒测定女性的血清瘦素水平。获取并比较了人体测量学和社会人口学数据。确定了怀孕期间的平均体重增加量。

结果

共有 170 名孕妇纳入了这项研究。肥胖孕妇足月时的平均血清瘦素水平（99.39±50.2ng/ml）和高瘦素血症的患病率（85 例中有 81 例；95.3%）显著高于非肥胖孕妇（48.98±30.35ng/ml/85 例中有 65 例；76.5%）。非肥胖孕妇足月时的平均体重增加百分比显著高于肥胖孕妇。参与者中足月时母体血清瘦素水平较高的预测因素是参与者的就业状况和教育水平。