Rachlin Audrey, Hampton Lee M, Rota Paul A, Mulders Mick N, Papania Mark, Goodson James L, Krause L Kendall, Hanson Matt, Osborn Jennifer, Kelly-Cirino Cassandra, Evans Beth, Sinha Antara, Warrener Lenesha, Featherstone David, Brown David
Global Immunization Division, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Vaccines (Basel). 2024 Jul 23;12(8):823. doi: 10.3390/vaccines12080823.
Efforts to control and eliminate measles and rubella are aided by high-quality surveillance data-supported by laboratory confirmation-to guide decision-making on routine immunization strategies and locations for conducting preventive supplementary immunization activities (SIAs) and outbreak response. Important developments in rapid diagnostic tests (RDTs) for measles and rubella present new opportunities for the global measles and rubella surveillance program to greatly improve the ability to rapidly detect and respond to outbreaks. Here, we review the status of RDTs for measles and rubella Immunoglobulin M (IgM) testing, as well as ongoing questions and challenges regarding the operational use and deployment of RDTs as part of global measles and rubella surveillance. Efforts to develop IgM RDTs that can be produced at scale are underway. Once validated RDTs are available, clear information on the benefits, challenges, and costs of their implementation will be critical for shaping deployment guidance and informing country plans for sustainably deploying such tests. The wide availability of RDTs could provide new programmatic options for measles and rubella elimination efforts, potentially enabling improvements and flexibility for testing, surveillance, and vaccination.
高质量的监测数据（辅以实验室确认）有助于麻疹和风疹的控制与消除工作，为常规免疫策略以及开展预防性补充免疫活动（SIAs）和疫情应对的地点提供决策依据。麻疹和风疹快速诊断检测（RDTs）的重要进展为全球麻疹和风疹监测计划带来了新机遇，极大地提升了快速检测和应对疫情的能力。在此，我们回顾了麻疹和风疹免疫球蛋白M（IgM）检测的RDTs现状，以及将RDTs作为全球麻疹和风疹监测一部分进行操作使用和部署时存在的问题与挑战。目前正在努力开发能够大规模生产的IgM RDTs。一旦获得经过验证的RDTs，有关其实施的益处、挑战和成本的清晰信息对于制定部署指南以及为各国可持续部署此类检测的计划提供参考至关重要。RDTs的广泛应用可为麻疹和风疹消除工作提供新的规划选项，有可能在检测、监测和疫苗接种方面实现改进并提高灵活性。
