Iqtadar Somia, Akram Javed, Khan Amjad
Dengue Expert Advisory Group, Lahore 54000, Pakistan.
Department of Medicine, King Edward Medical University, Lahore 54000, Pakistan.
Vaccines (Basel). 2024 Aug 13;12(8):913. doi: 10.3390/vaccines12080913.
Dengue fever, caused by the dengue virus (DENV), poses a significant global health threat, with a dramatic increase in cases driven by climate change, urbanization, and mosquito resistance. In Pakistan, a country with a population of 240 million, the world's fifth largest, dengue has emerged as an escalating public health crisis, with seasonal outbreaks severely straining the healthcare system. Despite decades of vector control efforts, there has not been much success, necessitating the introduction of dengue vaccination to boost population immunity. Recent advancements in vaccine development demonstrate promising efficacy and safety profiles, even in dengue-naive individuals. Implementing a dengue vaccination program in Pakistan could significantly reduce the disease burden, lower healthcare costs, and prevent future outbreaks. Integrating vaccination with existing public health initiatives can achieve high coverage and improve overall public health outcomes.
登革热由登革病毒（DENV）引起，对全球健康构成重大威胁，气候变化、城市化和蚊子抗药性导致病例急剧增加。在拥有2.4亿人口、世界第五大人口大国的巴基斯坦，登革热已演变成一场不断升级的公共卫生危机，季节性疫情使医疗系统不堪重负。尽管进行了数十年的病媒控制工作，但成效不大，因此有必要引入登革热疫苗以增强人群免疫力。疫苗研发的最新进展显示出有前景的疗效和安全性，即使对未曾感染过登革热的个体也是如此。在巴基斯坦实施登革热疫苗接种计划可显著减轻疾病负担、降低医疗成本并预防未来疫情。将疫苗接种与现有的公共卫生举措相结合可实现高覆盖率并改善总体公共卫生成果。
