de Miranda Victor Hugo Martins, Dos Santos Camila Paixão, Neves Pietra Petrica, Nascimento-Filho Antonio Viana, Dutra Marina Rascio Henriques, Bernardes Nathalia, Irigoyen Maria Claúdia, De Angelis Kátia
Physiology Department, Federal University of Sao Paulo (UNIFESP), Sao Paulo 04023-062, Brazil.
Laboratory of Translational Physiology, Nove de Julho University (UNINOVE), Sao Paulo 01525-000, Brazil.
Pharmaceuticals (Basel). 2024 Aug 10;17(8):1055. doi: 10.3390/ph17081055.
We investigate the role of galantamine on autonomic dysfunction associated with early cardiometabolic dysfunction in the offspring of fructose-overloaded rats.
rats received fructose diluted in drinking water (10%) or water for 60 days prior to mating. Fructose overload was maintained until the end of lactation. The offspring (21 days after birth) of control and fructose-overloaded animals were divided into three groups: control (C), fructose (F) and fructose + galantamine (GAL). GAL (5 mg/kg) was administered orally until the offspring were 51 days old. Metabolic, hemodynamic and cardiovascular autonomic modulation were evaluated.
The F group showed decreased insulin tolerance (KITT) compared to the C and GAL groups. The F group, in comparison to the C group, had increased arterial blood pressure, heart rate and sympathovagal balance (LF/HF ratio) and a low-frequency band of systolic arterial pressure (LF-SAP). The GAL group, in comparison to the F group, showed increased vagally mediated RMSSD index, a high-frequency band (HF-PI) and decreased LF/HF ratio and variance in SAP (VAR-SAP) and LF-SAP. Correlations were found between HF-PI and KITT (r = 0.60), heart rate (r = -0.65) and MAP (r = -0.71).
GAL treatment significantly improved cardiovascular autonomic modulation, which was associated with the amelioration of cardiometabolic dysfunction in offspring of parents exposed to chronic fructose consumption.
我们研究了加兰他敏对果糖超载大鼠后代早期心脏代谢功能障碍相关自主神经功能障碍的作用。
大鼠在交配前60天饮用含10%果糖的稀释水或普通水。果糖超载状态持续到哺乳期结束。将对照动物和果糖超载动物的后代（出生后21天）分为三组：对照组（C）、果糖组（F）和果糖+加兰他敏组（GAL）。口服给予加兰他敏（5mg/kg）直至后代51日龄。评估代谢、血流动力学和心血管自主神经调节功能。
与C组和GAL组相比，F组胰岛素耐量（KITT）降低。与C组相比，F组动脉血压、心率和交感迷走平衡（LF/HF比值）升高，收缩期动脉压低频带（LF-SAP）升高。与F组相比，GAL组迷走神经介导的RMSSD指数、高频带（HF-PI）升高，LF/HF比值、收缩期动脉压方差（VAR-SAP）和LF-SAP降低。发现HF-PI与KITT（r = 0.60）、心率（r = -0.65）和平均动脉压（r = -0.71）之间存在相关性。
加兰他敏治疗显著改善了心血管自主神经调节功能，这与长期摄入果糖的父母后代心脏代谢功能障碍的改善有关。
