Department of Pediatrics, Division of Endocrinology and Diabetes, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Pediatrics, Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Nutrients. 2021 Sep 20;13(9):3278. doi: 10.3390/nu13093278.
Developmental programming of chronic diseases by perinatal exposures/events is the basic tenet of the developmental origins hypothesis of adult disease (DOHaD). With consumption of fructose becoming more common in the diet, the effect of fructose exposure during pregnancy and lactation is of increasing relevance. Human studies have identified a clear effect of fructose consumption on maternal health, but little is known of the direct or indirect effects on offspring. Animal models have been utilized to evaluate this concept and an association between maternal fructose and offspring chronic disease, including hypertension and metabolic syndrome. This review will address the mechanisms of developmental programming by maternal fructose and potential options for intervention.
胎儿期暴露/事件对慢性疾病的发育编程是成人疾病发育起源假说（DOHaD）的基本原则。随着饮食中果糖消耗的日益普遍，妊娠和哺乳期暴露于果糖的影响变得越来越重要。人类研究已经确定了果糖摄入对母亲健康的明显影响，但对其对后代的直接或间接影响知之甚少。动物模型已被用于评估这一概念，以及母体果糖与后代慢性疾病（包括高血压和代谢综合征）之间的关联。这篇综述将讨论母体果糖的发育编程机制以及潜在的干预选择。
