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绿茶儿茶素表没食子儿茶素没食子酸酯抑制耐青霉素菌株PCr中营养细胞生长及β-内酰胺酶基因的表达。

Green Tea Catechin Epigallocatechin Gallate Inhibits Vegetative Cell Outgrowth and Expression of Beta-Lactamase Genes in Penicillin-Resistant Strain PCr.

作者信息

Okutani Akiko, Morikawa Shigeru, Maeda Ken

机构信息

Department of Veterinary Science, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.

出版信息

Pathogens. 2024 Aug 19;13(8):699. doi: 10.3390/pathogens13080699.

DOI:10.3390/pathogens13080699
PMID:39204299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11356866/
Abstract

The green tea catechin epigallocatechin gallate (EGCg) has antimicrobial effects on many bacteria. In this study, we investigated the inhibitory effects of EGCg on spores and vegetative cells. The spores were insensitive to EGCg, but the growth of vegetative cells derived from germinated spores was inhibited by EGCg. Moreover, EGCg decreased the minimum inhibitory concentration of penicillin and meropenem for penicillin-resistant . In the penicillin-resistant strain, the transcription levels of the beta-lactamase genes ( and ) decreased significantly following the treatment with 50 µg/mL EGCg. These results suggest that the appropriate application of EGCg may effectively control the penicillin-resistant growth and beta-lactamase production.

摘要

绿茶儿茶素表没食子儿茶素没食子酸酯（EGCg）对多种细菌具有抗菌作用。在本研究中，我们调查了EGCg对芽孢和营养细胞的抑制作用。芽孢对EGCg不敏感，但EGCg抑制了由萌发芽孢产生的营养细胞的生长。此外，EGCg降低了青霉素和美罗培南对耐青霉素菌的最低抑菌浓度。在耐青霉素菌株中，用50µg/mL EGCg处理后，β-内酰胺酶基因（和）的转录水平显著降低。这些结果表明，适当应用EGCg可能有效地控制耐青霉素菌的生长和β-内酰胺酶的产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/92083bbec2f0/pathogens-13-00699-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/d290d6cdbc39/pathogens-13-00699-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/d62e6981ebe8/pathogens-13-00699-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/9c0471ff5968/pathogens-13-00699-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/92083bbec2f0/pathogens-13-00699-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/d290d6cdbc39/pathogens-13-00699-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/d62e6981ebe8/pathogens-13-00699-g002a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/9c0471ff5968/pathogens-13-00699-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ecd/11356866/92083bbec2f0/pathogens-13-00699-g004.jpg

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本文引用的文献

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Microbiol Resour Announc. 2019 Aug 29;8(35):e00670-19. doi: 10.1128/MRA.00670-19.
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Comparative genomics and phylogenetic analysis of Bacillus anthracis strains isolated from domestic animals in Japan.比较基因组学和日本分离的家畜源炭疽芽胞杆菌菌株的系统发育分析。
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Molecules. 2018 May 9;23(5):1125. doi: 10.3390/molecules23051125.
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Green tea and epigallocatechin-3-gallate are bactericidal against Bacillus anthracis.绿茶和表没食子儿茶素-3-没食子酸酯对炭疽芽孢杆菌具有杀菌作用。
FEMS Microbiol Lett. 2017 Jul 3;364(12). doi: 10.1093/femsle/fnx127.
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