Szuba Magdalena, Stachera Weronika, Piwko Adrianna, Misiak Marianna, Rutkevich Renata, Sota Marcin, Atrushi Lana, Bennacer Leyla, Nzekea Deborah, Wu Yen Ching, Kim Arya Taesung, Yu Subin, Ribeiro Nash, Dybicz Monika
Department of General Biology and Parasitology, Medical University of Warsaw, 02-004 Warsaw, Poland.
Pathogens. 2024 Aug 20;13(8):703. doi: 10.3390/pathogens13080703.
Research on the therapeutic use of parasites has been ongoing since the development of the "hygiene hypothesis". Parasites can stimulate the Th2-dependent response and suppress the Th1-dependent response, which is intensified in many diseases, especially allergic and autoinflammatory ones. In this review, we present the types of parasites used in helminth therapy and the range of diseases in which they may be useful. We also present the results of clinical trials conducted so far, which confirm the safety of such therapy and provide promising outcomes.
自“卫生假说”提出以来，关于寄生虫治疗用途的研究一直在进行。寄生虫可刺激Th2依赖性反应并抑制Th1依赖性反应，而在许多疾病中，尤其是过敏性和自身炎症性疾病中，Th1依赖性反应会增强。在本综述中，我们介绍了蠕虫疗法中使用的寄生虫类型以及它们可能适用的疾病范围。我们还介绍了迄今为止进行的临床试验结果，这些结果证实了这种疗法的安全性并提供了有前景的结果。
