Wang Yifan, Zhang Chuyue, Cheng Junyao, Yan Taoxu, He Qing, Huang Da, Liu Jianheng, Wang Zheng
Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China.
Pharmaceutics. 2024 Jul 24;16(8):979. doi: 10.3390/pharmaceutics16080979.
Intervertebral disc degeneration (IVDD) stands as the foremost contributor to low back pain (LBP), imposing a substantial weight on the world economy. Traditional treatment modalities encompass both conservative approaches and surgical interventions; however, the former falls short in halting IVDD progression, while the latter carries inherent risks. Hence, the quest for an efficacious method to reverse IVDD onset is paramount. Biomaterial delivery systems, exemplified by hydrogels, microspheres, and microneedles, renowned for their exceptional biocompatibility, biodegradability, biological efficacy, and mechanical attributes, have found widespread application in bone, cartilage, and various tissue engineering endeavors. Consequently, IVD tissue engineering has emerged as a burgeoning field of interest. This paper succinctly introduces the intervertebral disc (IVD) structure and the pathophysiology of IVDD, meticulously classifies biomaterials for IVD repair, and reviews recent advances in the field. Particularly, the strengths and weaknesses of biomaterials in IVD tissue engineering are emphasized, and potential avenues for future research are suggested.
椎间盘退变（IVDD）是导致腰痛（LBP）的首要因素，给世界经济带来了沉重负担。传统的治疗方式包括保守治疗和手术干预；然而，前者在阻止IVDD进展方面效果不佳，而后者存在固有风险。因此，寻求一种有效的方法来逆转IVDD的发生至关重要。以水凝胶、微球和微针为代表的生物材料递送系统，因其卓越的生物相容性、生物可降解性、生物学功效和机械性能而闻名，已在骨、软骨和各种组织工程领域得到广泛应用。因此，IVD组织工程已成为一个新兴的研究领域。本文简要介绍了椎间盘（IVD）结构和IVDD的病理生理学，对用于IVD修复的生物材料进行了细致分类，并综述了该领域的最新进展。特别强调了生物材料在IVD组织工程中的优缺点，并提出了未来研究的潜在方向。
