Wirth Steffen, Schöler Martin, Brügmann Jonas, Leopold Claudia S
Department of Pharmaceutical Technology, University of Hamburg, Bundesstr. 45, 20146 Hamburg, Germany.
Fette Compacting GmbH, Grabauer Straße 24, 21493 Schwarzenbek, Germany.
Pharmaceutics. 2024 Aug 20;16(8):1088. doi: 10.3390/pharmaceutics16081088.
In the present study with a novel two-chamber setup (TCS) for dustiness investigations, the relationship between pressure differences as well as air velocities and the resulting dust emissions is investigated. The dust emissions of six particle size fractions of acetaminophen at pressure differences between 0 and 12 Pa are examined. The results show that both simulated and measured air velocities increase with increasing pressure difference. Dust emissions decrease significantly with increasing pressure difference and air velocity. Fine particles cause higher dust emissions than coarse particles. A high goodness of fit is obtained with exponential and quadratic functions to describe the relationship between pressure difference and dust emission, indicating that even moderate increases in pressure may lead to a reduction in the emission. Average air velocities within the TCS simulated with Computational Fluid Dynamics are between 0.09 and 0.37 m/s, whereas those measured experimentally are between 0.09 and 0.41 m/s, both ranges corresponding to the recommended values for effective particle separation in containment systems. These results underline the ability of the novel TCS to control pressure and airflow, which is essential for reliable dust emission measurements and thus provide support for further scientific and industrial applications.
在本研究中，采用一种用于粉尘研究的新型双室装置（TCS），研究了压差、空气流速与由此产生的粉尘排放之间的关系。研究了对乙酰氨基酚六个粒径级分在0至12 Pa压差下的粉尘排放情况。结果表明，模拟和实测的空气流速均随压差增大而增加。粉尘排放随压差和空气流速的增加而显著降低。细颗粒比粗颗粒产生的粉尘排放更高。用指数函数和二次函数描述压差与粉尘排放之间的关系，拟合优度较高，这表明即使压差适度增加也可能导致排放减少。用计算流体动力学模拟的TCS内的平均空气流速在0.09至0.37 m/s之间，而实验测量的平均空气流速在0.09至0.41 m/s之间，这两个范围均对应于密闭系统中有效颗粒分离的推荐值。这些结果强调了新型TCS控制压力和气流的能力，这对于可靠的粉尘排放测量至关重要，从而为进一步的科学和工业应用提供了支持。
