Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
Asian Pac J Cancer Prev. 2024 Aug 1;25(8):2823-2830. doi: 10.31557/APJCP.2024.25.8.2823.
CRC is going to be an important issue in Middle East countries. Also, the main parts of this cancer develop from benign adenomas.
To understand the recurrence rate of colorectal polyps among average-risk subjects.
In a prospective study, the average-risk patients with colorectal adenoma were enrolled in this study based on inclusion criteria. The patients were consulted annually by an expert gastroenterologist. A control colonoscopy was programmed after three years of follow-up. It was not an obligation to follow our program, and each patient could exit the study at any time. The patient who developed one of the exclusion criteria was also withdrawn from the study by the gastroenterologist of this study.
237 patients were enrolled in this study. Of them, 102 patients completed their 3-year follow-up. Among these participants, 62 (60.8%) were male and 40 (39.2%) were female, with a mean age of 57.05 ± 12.87 years. Additionally, 20 (19.6%) subjects had adenomatous polyps at the end of the study. Patients with recurrent colorectal polyps tend to be raised in large ones with a tubulovillous morphology. The polyps were more commonly located in the sigmoid colon, rectum. Furthermore, high-grade dysplasia was recorded in 5 patients. Tubulovillous polyp had higher chance of recurrence than patients with tubular polyp.
We believe the colonoscopy screening needs to be set up in regions previously considered low-risk for CRC. Also, it may be valuable to control colonoscopy for less than three years in patients with dysplasia.
CRC 将成为中东国家的一个重要问题。此外，这种癌症的主要部分是由良性腺瘤发展而来的。
了解普通风险人群结直肠息肉的复发率。
在一项前瞻性研究中，根据纳入标准，招募了结直肠腺瘤的普通风险患者。专家级胃肠病学家每年对患者进行咨询。在随访 3 年后，安排了对照结肠镜检查。遵循我们的方案并不是强制性的，每个患者都可以在任何时候退出研究。当患者出现排除标准之一时，也会被该研究的胃肠病学家退出研究。
本研究共纳入 237 例患者。其中，102 例患者完成了 3 年随访。这些参与者中，62 例（60.8%）为男性，40 例（39.2%）为女性，平均年龄为 57.05±12.87 岁。此外，20 例（19.6%）患者在研究结束时发现有腺瘤性息肉。复发结直肠息肉的患者倾向于瘤体较大，呈管状绒毛状形态。息肉更常见于乙状结肠、直肠。此外，有 5 例患者记录到高级别异型增生。管状绒毛状息肉比管状息肉更有复发的可能。
我们认为，先前被认为 CRC 风险较低的地区需要进行结肠镜筛查。此外，对于有异型增生的患者，控制结肠镜检查的时间少于 3 年可能是有价值的。
