Alkaissi Hussam, Kim Emily J, Salahi Navid, McFarlane Samy I
Endocrinology, Diabetes and Metabolism, National Institutes of Health (NIH), Bethesda, USA.
Internal Medicine, Kings County Hospital Center, Brooklyn, USA.
Cureus. 2024 Jul 29;16(7):e65639. doi: 10.7759/cureus.65639. eCollection 2024 Jul.
Granulomatous lobular mastitis (GLM) is a rare, benign inflammatory disease of the breast that shares some physical diagnostic features with breast cancer. GLM has been rarely reported to be associated with prolactinoma. In this report, we present a case of undiagnosed prolactinoma in a 37-year-old woman with its initial presentation as GLM. We discuss the underlying pathophysiologic mechanisms for the development of GLM and the potential immunomodulatory role of prolactin in the development of GLM. We also highlight the need to assess for possible prolactinoma in GLM, which might go undiagnosed as in the case of our patient who did not seek medical attention for her amenorrhea, which is likely due to hyperprolactinemia that might also have other clinical implications on cardiovascular and bone health due to consequent estrogen deficiency.
肉芽肿性小叶性乳腺炎（GLM）是一种罕见的乳腺良性炎症性疾病，在体格检查方面与乳腺癌有一些共同特征。GLM与泌乳素瘤相关的报道极为罕见。在本报告中，我们呈现了一例37岁女性，最初表现为GLM，后被诊断出患有未确诊的泌乳素瘤。我们讨论了GLM发生发展的潜在病理生理机制以及泌乳素在GLM发生中的潜在免疫调节作用。我们还强调了在GLM患者中评估是否存在可能的泌乳素瘤的必要性，就像我们的患者那样，她因闭经未就医，而闭经可能是由于高泌乳素血症所致，高泌乳素血症还可能因随之而来的雌激素缺乏对心血管和骨骼健康产生其他临床影响。
