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一名患有房间隔缺损和胎儿酒精综合征患者的继发性肺动脉高压病例。

A Case of Secondary Pulmonary Hypertension in a Patient With Atrial Septal Defect and Fetal Alcohol Syndrome.

作者信息

Pirnat Maja, Lesjak Vesna, Šuran David, Lovrec Orthaber Tina

机构信息

Department of Radiology, Maribor University Medical Centre, Maribor, SVN.

Department of Cardiology and Angiology, Maribor University Medical Centre, Maribor, SVN.

出版信息

Cureus. 2024 Jul 28;16(7):e65611. doi: 10.7759/cureus.65611. eCollection 2024 Jul.

DOI:10.7759/cureus.65611
PMID:39205751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357726/
Abstract

We report a case of a 34-year-old man with fetal alcohol syndrome (FAS) presenting with dyspnea, cough, and hoarse voice. The patient was found to have severe pulmonary hypertension secondary to a large atrial septal defect (ASD). In this article, we discuss the challenges patients with FAS and other patients with cognitive impairments face that could explain the first diagnosis of such a large cardiac birth defect being made in the patient's adulthood. Moreover, severe pulmonary hypertension due to ASD also presents a therapeutic dilemma, as shunt closure can lead to a worsening of the condition.

摘要

我们报告一例34岁患有胎儿酒精综合征（FAS）的男性患者，其表现为呼吸困难、咳嗽和声音嘶哑。该患者被发现患有继发于大型房间隔缺损（ASD）的严重肺动脉高压。在本文中，我们讨论了FAS患者和其他认知障碍患者所面临的挑战，这些挑战可以解释为何该患者在成年期才首次诊断出如此大型的先天性心脏缺陷。此外，ASD所致的严重肺动脉高压也带来了治疗困境，因为封堵分流可能会导致病情恶化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/10beeed6fea4/cureus-0016-00000065611-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/1bb8b52751ff/cureus-0016-00000065611-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/858f97481ba0/cureus-0016-00000065611-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/88f15fa8e648/cureus-0016-00000065611-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/10beeed6fea4/cureus-0016-00000065611-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/1bb8b52751ff/cureus-0016-00000065611-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/858f97481ba0/cureus-0016-00000065611-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/88f15fa8e648/cureus-0016-00000065611-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb1f/11357726/10beeed6fea4/cureus-0016-00000065611-i04.jpg

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本文引用的文献

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Birth Defects Associated with Prenatal Alcohol Exposure-A Review.产前酒精暴露相关出生缺陷——综述
Children (Basel). 2023 Apr 29;10(5):811. doi: 10.3390/children10050811.
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Impact of Patient Mild Cognitive Impairment on Physician Decision-Making for Treatment.患者轻度认知障碍对医生治疗决策的影响。
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Birth Defects Res. 2021 Apr 15;113(7):521-534. doi: 10.1002/bdr2.1743. Epub 2020 Jun 24.
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Eur J Prev Cardiol. 2020 Mar;27(4):410-421. doi: 10.1177/2047487319874530. Epub 2019 Oct 2.
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Atrial septal defect with pulmonary hypertension: when/how can we consider closure?房间隔缺损合并肺动脉高压：我们何时/如何考虑封堵治疗？
J Thorac Dis. 2018 Sep;10(Suppl 24):S2890-S2898. doi: 10.21037/jtd.2018.07.112.
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Comparison of Echocardiography and 64-Multislice Spiral Computed Tomography for the Diagnosis of Pediatric Congenital Heart Disease.超声心动图与64层螺旋计算机断层扫描在小儿先天性心脏病诊断中的比较
Med Sci Monit. 2017 May 13;23:2258-2266. doi: 10.12659/msm.901546.
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Professional Education, Training and Role of the Cardiac Sonographer in Different Countries.不同国家心脏超声检查技师的专业教育、培训及角色
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Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders.《胎儿酒精谱系障碍诊断临床指南（更新版）》
Pediatrics. 2016 Aug;138(2). doi: 10.1542/peds.2015-4256. Epub 2016 Jul 27.
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Prenatal Alcohol Exposure and Congenital Heart Defects: A Meta-Analysis.产前酒精暴露与先天性心脏病：一项荟萃分析。
PLoS One. 2015 Jun 25;10(6):e0130681. doi: 10.1371/journal.pone.0130681. eCollection 2015.
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Exploring the potential to use data linkage for investigating the relationship between birth defects and prenatal alcohol exposure.探索利用数据关联来研究出生缺陷与产前酒精暴露之间关系的潜力。
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