Dyląg Katarzyna Anna, Anunziata Florencia, Bandoli Gretchen, Chambers Christina
Department of Pathophysiology, Jagiellonian University Medical College, Czysta 18, 31-121 Krakow, Poland.
St. Louis Children Hospital, ul. Strzelecka 2, 31-503 Krakow, Poland.
Children (Basel). 2023 Apr 29;10(5):811. doi: 10.3390/children10050811.
Since the recognition of fetal alcohol syndrome, alcohol has been accepted as a human teratogen. However, little is known about the relation between prenatal alcohol exposure and the spectrum of associated major birth defects. The objective of this review was to summarize data on the association of major congenital abnormalities and prenatal alcohol exposure. We included all major birth defects according to ICD-10 classification. We found that the strongest evidence to date lies in the research examining herniation (gastroschisis and omphalocele), oral clefts (cleft lip with or without palate and cleft palate) and cardiac defects. There is less consistent evidence supporting the association between prenatal alcohol exposure and anomalies of gastrointestinal system, diaphragmatic hernia, genitourinary system and neural tube defects. We found no material support for PAE and choanal atresia, biliary atresia or clubfoot.
自胎儿酒精综合征被确认以来，酒精已被公认为一种人类致畸剂。然而，关于产前酒精暴露与相关主要出生缺陷谱之间的关系，人们所知甚少。本综述的目的是总结关于主要先天性异常与产前酒精暴露之间关联的数据。我们纳入了根据国际疾病分类第10版（ICD - 10）分类的所有主要出生缺陷。我们发现，迄今为止最有力的证据存在于对疝（腹裂和脐膨出）、口腔裂隙（唇裂伴或不伴腭裂以及腭裂）和心脏缺陷的研究中。关于产前酒精暴露与胃肠道系统异常、膈疝、泌尿生殖系统和神经管缺陷之间的关联，证据不太一致。我们没有发现关于产前酒精暴露与后鼻孔闭锁、胆道闭锁或马蹄内翻足之间的实质性支持证据。
