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本文引用的文献

1
ECT beyond unipolar major depression: systematic review and meta-analysis of electroconvulsive therapy in bipolar depression.双相抑郁中的电抽搐治疗:电抽搐治疗在单相重度抑郁症之外的应用:系统回顾和荟萃分析。
Acta Psychiatr Scand. 2019 Mar;139(3):214-226. doi: 10.1111/acps.12994. Epub 2018 Dec 16.
2
Extreme variability in succinylcholine dose for muscle relaxation in electroconvulsive therapy.电休克治疗中用于肌肉松弛的琥珀酰胆碱剂量存在极大差异。
Australas Psychiatry. 2018 Aug;26(4):391-393. doi: 10.1177/1039856218761301. Epub 2018 Mar 5.
3
Pseudocholinesterase levels in patients under electroconvulsive therapy.接受电休克治疗患者的假性胆碱酯酶水平。
Saudi Med J. 2018 Jan;39(1):103-106. doi: 10.15537/smj.2018.1.21307.
4
Methohexital and succinylcholine dosing for electroconvulsive therapy (ECT): actual versus ideal.依托咪酯和琥珀酰胆碱用于电抽搐治疗(ECT)的剂量:实际与理想。
J ECT. 2012 Sep;28(3):e29-30. doi: 10.1097/YCT.0b013e3182503bc9.
5
The predisposition to inspiratory upper airway collapse during partial neuromuscular blockade.部分神经肌肉阻滞期间吸气性上气道塌陷的易感性。
Am J Respir Crit Care Med. 2007 Jan 1;175(1):9-15. doi: 10.1164/rccm.200512-1862OC. Epub 2006 Oct 5.
6
The dose of succinylcholine in morbid obesity.病态肥胖患者中琥珀酰胆碱的剂量
Anesth Analg. 2006 Feb;102(2):438-42. doi: 10.1213/01.ane.0000194876.00551.0e.
7
Anesthesia for electroconvulsive therapy.电休克治疗的麻醉
Anesth Analg. 2002 May;94(5):1351-64. doi: 10.1097/00000539-200205000-00057.
8
An intrasubject comparison of two doses of succinylcholine in modified electroconvulsive therapy.改良电休克治疗中两种剂量琥珀酰胆碱的受试者内比较。
Anesth Analg. 1999 Nov;89(5):1301-4.
9
Critical hemoglobin desaturation will occur before return to an unparalyzed state following 1 mg/kg intravenous succinylcholine.静脉注射1mg/kg琥珀酰胆碱后,在恢复至非麻痹状态之前会出现严重的血红蛋白去饱和。
Anesthesiology. 1997 Oct;87(4):979-82. doi: 10.1097/00000542-199710000-00034.

在一名病态肥胖患者中使用较小剂量琥珀酰胆碱减少电休克治疗(ECT)期间的呼吸并发症:病例报告

Reducing Respiratory Complications During Electroconvulsive Therapy (ECT) With Smaller Doses of Succinylcholine in a Morbidly Obese Patient: A Case Report.

作者信息

Zhang Rensheng V, Carr Brent R

机构信息

Department of Anesthesiology, University of Florida College of Medicine, Gainesville, USA.

Department of Psychiatry, University of Florida College of Medicine, Gainesville, USA.

出版信息

Cureus. 2024 Jul 29;16(7):e65654. doi: 10.7759/cureus.65654. eCollection 2024 Jul.

DOI:10.7759/cureus.65654
PMID:39205780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11351955/
Abstract

Anesthesia for electroconvulsive therapy (ECT) requires proper medications and airway management. Besides an induction agent such as methohexital, a neuromuscular blocker such as succinylcholine (SCh) is often given for muscle relaxation. To maintain the patient's oxygen saturation, mask ventilation is required due to this transient chemical paralysis even in the presence of adequate preoxygenation. A morbidly obese, middle-aged female experienced multiple life-threatening hypoxic episodes due to "bronchospasms" during prior ECT treatments. A drastic reduction in the SCh dose to about half of the original dose led to much smoother anesthesia courses with no more hypoxic episodes during subsequent ECT treatments. We believe that the lower dosing of SCh avoided a long period of chemical paralysis, which led to a quick return of spontaneous respiration, shortened the need for airway support, and therefore avoided hypoxic episodes in subsequent ECT treatments.

摘要

电休克治疗(ECT)的麻醉需要合适的药物和气道管理。除了像美索比妥这样的诱导剂外,通常还会给予琥珀酰胆碱(SCh)等神经肌肉阻滞剂以实现肌肉松弛。为维持患者的氧饱和度,即便进行了充分的预给氧,由于这种短暂的化学性麻痹仍需面罩通气。一名病态肥胖的中年女性在先前的ECT治疗期间因“支气管痉挛”经历了多次危及生命的缺氧发作。将SCh剂量大幅减少至原剂量的约一半,使得后续ECT治疗期间的麻醉过程更加平稳,不再出现缺氧发作。我们认为,较低剂量的SCh避免了长时间的化学性麻痹,从而使自主呼吸迅速恢复,缩短了气道支持的需求,进而避免了后续ECT治疗中的缺氧发作。