Liskowsky D R, Potter L T
Neurosci Lett. 1985 Jan 21;53(2):161-7. doi: 10.1016/0304-3940(85)90179-x.
The distribution of L-3,4-dihydroxy-[3H]phenylalanine (L-[3H]DOPA) was examined in rats following i.v. injection, to ascertain the possible usefulness of using this ligand to image dopaminergic systems using positron emission tomography. It was found that L-DOPA and its metabolites were preferentially localized in the basal ganglia as compared to other brain regions, and that this preferential localization could be abolished by lesioning of the nigro-striatal tract. The parameters of the L-DOPA uptake and the sensitivity of this uptake to alterations in dopaminergic pathways indicate that this ligand may be useful in visualizing aberrations in dopaminergic pathways in various pathological conditions.
静脉注射后，对大鼠体内L-3,4-二羟基-[3H]苯丙氨酸（L-[3H]多巴）的分布进行了研究，以确定使用该配体通过正电子发射断层扫描对多巴胺能系统进行成像的潜在用途。结果发现，与其他脑区相比，L-多巴及其代谢产物优先定位于基底神经节，并且这种优先定位可通过黑质纹状体束损伤而消除。L-多巴摄取的参数以及该摄取对多巴胺能途径改变的敏感性表明，该配体可能有助于在各种病理状况下可视化多巴胺能途径的异常。
