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M1谱系在新西兰奥特亚罗瓦侵袭性A组链球菌疾病中的出现及影响

The Emergence and Impact of the M1 Lineage on Invasive Group A Streptococcus Disease in Aotearoa New Zealand.

作者信息

Vesty Anna, Ren Xiaoyun, Sharma Prachi, Lorenz Natalie, Proft Thomas, Hardaker Allan, Straub Christina, Morgan Julie, Tiong Audrey, Anderson Anneka, Webb Rachel H, Bennett Julie, Carter Philip E, Moreland Nicole J

机构信息

The Institute of Environment Science and Research, Porirua, New Zealand.

School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

出版信息

Open Forum Infect Dis. 2024 Aug 9;11(8):ofae457. doi: 10.1093/ofid/ofae457. eCollection 2024 Aug.

DOI:10.1093/ofid/ofae457
PMID:39205925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11350281/
Abstract

M1 is associated with current surges in invasive infection globally, partly due to increased production of superantigen streptococcal pyrogenic exotoxin A. We show that M1 is now the dominant invasive 1 lineage in Aotearoa New Zealand and is genomically related to community infections, suggesting that measures that effectively prevent group A pharyngitis in children could reduce invasive disease.

摘要

M1与全球侵袭性感染中的当前感染激增有关，部分原因是超抗原链球菌致热外毒素A的产生增加。我们发现，M1现在是新西兰奥特亚罗瓦侵袭性1谱系中的主要类型，并且在基因组上与社区感染相关，这表明有效预防儿童A组咽炎的措施可能会减少侵袭性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1526/11350281/f89fd7e4f24c/ofae457f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1526/11350281/f89fd7e4f24c/ofae457f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1526/11350281/f89fd7e4f24c/ofae457f1.jpg

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