Hadi H A, Fadel H E, Nelson G H, Hill J
Obstet Gynecol. 1985 May;65(5):758-60.
Amniotic fluid spectrophotometric analysis for bilirubin (delta optical density [delta OD450], at 450 nm) is used to assess the severity of fetal involvement in isoimmunized pregnancies. Two patients presented with sickle cell anemia and hyperbilirubinemia who also were isoimmunized. The first patient had anti-kell and anti-e antibodies, whereas the second patient had anti-Lewisa and anti-Coltonb antibodies. Delta OD450 was elevated in both patients. The difficulty in interpretation of high delta OD450 in the presence of maternal hyperbilirubinemia is stressed. Sickle cell diseased patients are particularly prone to present with this problem. These patients always have hyperbilirubinemia and a relatively high incidence of irregular antibodies because of the numerous blood transfusions they receive. The management of these two patients is presented with suggestions for the use of alternative modalities of monitoring isoimmunized pregnancies in patients with hyperbilirubinemia.
羊水胆红素分光光度分析（450nm处的δ光密度[δOD450]）用于评估胎儿在母儿血型不合妊娠中的受累严重程度。两名患有镰状细胞贫血和高胆红素血症的患者也存在母儿血型不合。第一名患者有抗凯尔和抗E抗体，而第二名患者有抗刘易斯a和抗科尔顿b抗体。两名患者的δOD450均升高。强调了在母亲高胆红素血症情况下解释高δOD450的困难。镰状细胞病患者特别容易出现这个问题。这些患者由于接受大量输血，总是存在高胆红素血症且不规则抗体发生率相对较高。本文介绍了这两名患者的治疗情况，并对高胆红素血症患者监测母儿血型不合妊娠的替代方法的使用提出了建议。
