Salomon David, Fruscalzo Arrigo, Boulvain Michel, Feki Anis, Ben Ali Nordine
Department of Obstetrics and Gynecology, Cantonal Hospital, University of Fribourg, Fribourg, Switzerland.
Front Med (Lausanne). 2024 Aug 14;11:1439716. doi: 10.3389/fmed.2024.1439716. eCollection 2024.
Small-for-gestational-age (SGA) fetuses are at increased risk of mortality and morbidity, and less than 30% will be detected by any ultrasound scan within 4 weeks before delivery. Our aim was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) in the first trimester of pregnancy and SGA fetuses.
We performed a prospective study between June 2021 and August 2022, to evaluate the relationship between the neutrophil to lymphocyte ratio in maternal blood in the first trimester of pregnancy, with the birth of an SGA fetus. One hundred ninety-four participants with singleton pregnancies between 11 + 1 and 13 + 6 weeks of gestation were recruited. Pregnancies affected with diagnosed fetal chromosomal abnormalities, or chronic pathologies were excluded. SGA was defined as birthweight less than the 10th centile ( = 42) and severe SGA as birthweight less than the 3rd centile for gestation ( = 10) according to a locally derived descriptive charts. The NLR value measured in the first trimester was compared between these two groups and controls.
We found no statistically significant difference in NLR, (3.5 +/-1.2 vs. 3.4+/-1.2, -value of 0.78) when comparing the SGA less than the 10th centile group to the control group. NLR was also not different between severe SGA and controls (3.6+/-1.4 vs. 3.4+/-1.2 -value of 0.78).
We found no association between first-trimester NLR ratio and SGA.
小于胎龄（SGA）胎儿的死亡和发病风险增加，且在分娩前4周内通过任何超声扫描检测到的此类胎儿不到30%。我们的目的是评估妊娠早期中性粒细胞/淋巴细胞比值（NLR）与SGA胎儿之间的关系。
我们在2021年6月至2022年8月期间进行了一项前瞻性研究，以评估妊娠早期母体血液中中性粒细胞与淋巴细胞比值与SGA胎儿出生之间的关系。招募了194名妊娠11+1至13+6周的单胎妊娠参与者。排除诊断为胎儿染色体异常或慢性疾病的妊娠。根据本地得出的描述性图表，SGA定义为出生体重低于第10百分位数（n = 42），严重SGA定义为出生体重低于妊娠第3百分位数（n = 10）。比较这两组与对照组在妊娠早期测量的NLR值。
将小于第10百分位数的SGA组与对照组进行比较时，我们发现NLR无统计学显著差异（3.5 +/-1.2 vs. 3.4+/-1.2，p值为0.78）。严重SGA组与对照组之间的NLR也无差异（3.6+/-1.4 vs. 3.4+/-1.2，p值为0.78）。
我们发现妊娠早期NLR比值与SGA之间无关联。
