Huang You, Wu Qiuhong, Li Sha, Lin Xia, Yang Shasha, Zhu Rui, Fu Chaomei, Zhang Zhen
School of Pharmacy/School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2024 Aug 14;15:1394124. doi: 10.3389/fphar.2024.1394124. eCollection 2024.
Ulcerative colitis (UC) is a form of chronic inflammatory bowel disease, and UC diagnosis rates continue to rise throughout the globe. The research and development of new drugs for the treatment of UC are urgent, and natural compounds are an important source. However, there is a lack of systematic summarization of natural compounds and their mechanisms for the treatment of UC.
We reviewed the literature in the databases below from their inception until July 2023: Web of Science, PubMed, China National Knowledge Infrastructure, and Wanfang Data, to obtain information on the relationship between natural compounds and UC.
The results showed that 279 natural compounds treat UC through four main mechanisms, including regulating gut microbiota and metabolites (Mechanism I), protecting the intestinal mucosal barrier (Mechanism II), regulating intestinal mucosal immune response (Mechanism III), as well as regulating other mechanisms (Mechanism Ⅳ) such as cellular autophagy modulation and ferroptosis inhibition. Of these, Mechanism III is regulated by all natural compounds. The 279 natural compounds, including 62 terpenoids, 57 alkaloids, 52 flavonoids, 26 phenols, 19 phenylpropanoids, 9 steroids, 9 saponins, 8 quinonoids, 6 vitamins, and 31 others, can effectively ameliorate UC. Of these, terpenoids, alkaloids, and flavonoids have the greatest potential for treating UC. It is noteworthy to highlight that a total of 54 natural compounds exhibit their therapeutic effects by modulating Mechanisms I, II, and III.
This review serves as a comprehensive resource for the pharmaceutical industry, researchers, and clinicians seeking novel therapeutic approaches to combat UC. Harnessing the therapeutic potential of these natural compounds may significantly contribute to the improvement of the quality of life of patients with UC and promotion of disease-modifying therapies in the future.
溃疡性结肠炎（UC）是一种慢性炎症性肠病，全球范围内UC的诊断率持续上升。研发治疗UC的新药迫在眉睫，天然化合物是一个重要来源。然而，目前缺乏对天然化合物及其治疗UC机制的系统总结。
我们检索了以下数据库从建库至2023年7月的文献：科学网、PubMed、中国知网和万方数据，以获取天然化合物与UC关系的信息。
结果显示，279种天然化合物通过四种主要机制治疗UC，包括调节肠道微生物群和代谢物（机制I）、保护肠道黏膜屏障（机制II）、调节肠道黏膜免疫反应（机制III）以及调节其他机制（机制IV），如细胞自噬调节和铁死亡抑制。其中，机制III受所有天然化合物调节。这279种天然化合物，包括62种萜类、57种生物碱、52种黄酮类、26种酚类、19种苯丙素类、9种甾体、9种皂苷、8种醌类、6种维生素和31种其他化合物，可有效改善UC。其中，萜类、生物碱和黄酮类治疗UC的潜力最大。值得注意的是，共有54种天然化合物通过调节机制I、II和III发挥治疗作用。
本综述为制药行业、研究人员和临床医生寻求对抗UC的新治疗方法提供了全面的资源。利用这些天然化合物的治疗潜力可能会显著有助于改善UC患者的生活质量，并在未来推动疾病改善疗法的发展。
