• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

掩盖药物苦味的主要挑战之一：苦味定量方法概述

One of the major challenges of masking the bitter taste in medications: an overview of quantitative methods for bitterness.

作者信息

Wang Panpan, Li Haiyang, Wang Yanli, Dong Fengyu, Li Han, Gui Xinjing, Ren Yanna, Gao Xiaojie, Li Xuelin, Liu Ruixin

机构信息

Department of Pharmacy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.

出版信息

Front Chem. 2024 Aug 14;12:1449536. doi: 10.3389/fchem.2024.1449536. eCollection 2024.

DOI:10.3389/fchem.2024.1449536
PMID:39206439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11349634/
Abstract

OBJECTIVE

The aim of the present study was to carry out a systematic research on bitterness quantification to provide a reference for scholars and pharmaceutical developers to carry out drug taste masking research. Significance: The bitterness of medications poses a significant concern for clinicians and patients. Scientifically measuring the intensity of drug bitterness is pivotal for enhancing drug palatability and broadening their clinical utility.

METHODS

The current study was carried out by conducting a systematic literature review that identified relevant papers from indexed databases. Numerous studies and research are cited and quoted in this article to summarize the features, strengths, and applicability of quantitative bitterness assessment methods.

RESULTS

In our research, we systematically outlined the classification and key advancements in quantitative research methods for assessing drug bitterness, including quantification techniques such as traditional human taste panel methods, as well as quantification methods such as electronic tongue analysis. It focused on the quantitative methods and difficulties of bitterness of natural drugs with complex system characteristics and their difficulties in quantification, and proposes possible future research directions.

CONCLUSION

The quantitative methods of bitterness were summarized, which laid an important foundation for the construction of a comprehensive bitterness quantification standard system and the formulation of accurate, efficient and rich taste masking strategies.

摘要

目的

本研究旨在对苦味量化进行系统研究，为学者和药物研发人员开展药物掩味研究提供参考。意义：药物的苦味是临床医生和患者极为关注的问题。科学测量药物苦味强度对于提高药物适口性和拓展其临床应用至关重要。

方法

本研究通过对索引数据库进行系统的文献综述来开展，识别相关论文。本文引用和参考了大量研究，以总结定量苦味评估方法的特点、优势和适用性。

结果

在我们的研究中，我们系统地概述了评估药物苦味的定量研究方法的分类和关键进展，包括传统人体味觉小组方法等量化技术，以及电子舌分析等量化方法。重点关注具有复杂系统特征的天然药物苦味的定量方法及其量化难点，并提出了未来可能的研究方向。

结论

总结了苦味的定量方法，为构建全面的苦味量化标准体系和制定准确、高效、丰富的掩味策略奠定了重要基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/e9bf4b9aa23a/fchem-12-1449536-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/c6b6e71719ec/fchem-12-1449536-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/b42fe002fc6e/fchem-12-1449536-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/78b8a9ce15b2/fchem-12-1449536-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/6992956f3d79/fchem-12-1449536-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/9417c74ecfb0/fchem-12-1449536-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/91cf8822dd85/fchem-12-1449536-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/359e4ea9cf74/fchem-12-1449536-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/e9bf4b9aa23a/fchem-12-1449536-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/c6b6e71719ec/fchem-12-1449536-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/b42fe002fc6e/fchem-12-1449536-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/78b8a9ce15b2/fchem-12-1449536-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/6992956f3d79/fchem-12-1449536-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/9417c74ecfb0/fchem-12-1449536-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/91cf8822dd85/fchem-12-1449536-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/359e4ea9cf74/fchem-12-1449536-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/11349634/e9bf4b9aa23a/fchem-12-1449536-g008.jpg

相似文献

1
One of the major challenges of masking the bitter taste in medications: an overview of quantitative methods for bitterness.掩盖药物苦味的主要挑战之一：苦味定量方法概述
Front Chem. 2024 Aug 14;12:1449536. doi: 10.3389/fchem.2024.1449536. eCollection 2024.
2
In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex.采用含有离子交换树脂-药物复合物的口腔崩解片进行崩解和掩味的体外与体内相关性研究。
Int J Pharm. 2013 Oct 15;455(1-2):31-9. doi: 10.1016/j.ijpharm.2013.07.072. Epub 2013 Aug 7.
3
Taste masking analysis in pharmaceutical formulation development using an electronic tongue.使用电子舌进行药物制剂开发中的味觉掩盖分析。
Int J Pharm. 2006 Mar 9;310(1-2):118-24. doi: 10.1016/j.ijpharm.2005.11.046. Epub 2006 Jan 20.
4
Taste Sensor Assessment of Bitterness in Medicines: Overview and Recent Topics.药物苦味的味觉传感器评估：概述及最新研究课题。
Sensors (Basel). 2024 Jul 24;24(15):4799. doi: 10.3390/s24154799.
5
Utilization of a modified special-cubic design and an electronic tongue for bitterness masking formulation optimization.利用改良的特殊立方设计和电子舌进行苦味掩盖配方优化。
J Pharm Sci. 2007 Oct;96(10):2723-34. doi: 10.1002/jps.20900.
6
An electronic tongue: evaluation of the masking efficacy of sweetening and/or flavoring agents on the bitter taste of epinephrine.电子舌：评估甜味剂和/或调味剂对肾上腺素苦味掩蔽效果的评价。
AAPS PharmSciTech. 2010 Jun;11(2):550-7. doi: 10.1208/s12249-010-9402-3. Epub 2010 Mar 30.
7
[Study on superposition law of drug bitterness based on tongue taste evaluation and electronic tongue evaluation].基于舌味觉评价和电子舌评价的药物苦味叠加规律研究
Zhongguo Zhong Yao Za Zhi. 2019 Dec;44(23):5134-5142. doi: 10.19540/j.cnki.cjcmm.20190916.310.
8
[Structure-activity relationship of coptis alkaloid bitterness inhibited by mPEG-PLLA].[甲氧基聚乙二醇-聚乳酸抑制黄连生物碱苦味的构效关系]
Zhongguo Zhong Yao Za Zhi. 2020 Jul;45(13):3128-3135. doi: 10.19540/j.cnki.cjcmm.20200424.301.
9
Bitterness prediction in-silico: A step towards better drugs.苦味预测的计算方法：迈向更好药物的一步。
Int J Pharm. 2018 Feb 5;536(2):526-529. doi: 10.1016/j.ijpharm.2017.03.076. Epub 2017 Mar 28.
10
Bitter taste masking of enzyme-treated soy protein in water and bread.酶处理大豆蛋白在水和面包中的苦味掩蔽。
J Sci Food Agric. 2018 Aug;98(10):3860-3869. doi: 10.1002/jsfa.8903. Epub 2018 Mar 23.

本文引用的文献

1
Potential of Bitter Medicinal Plants: A Review of Flavor Physiology.苦味药用植物的潜力：风味生理学综述
Pharmaceuticals (Basel). 2024 Jun 3;17(6):722. doi: 10.3390/ph17060722.
2
Bitter flavors and bitter compounds in foods: identification, perception, and reduction techniques.食物中的苦味和苦味化合物：鉴定、感知和减少技术。
Food Res Int. 2024 May;183:114234. doi: 10.1016/j.foodres.2024.114234. Epub 2024 Mar 13.
3
Taste assessment for paediatric drug Development: A comparison of bitterness taste aversion in children versus Naïve and expert young adult assessors.
儿童药物开发的味觉评估：儿童与天真和专业青年评估者的苦味味觉厌恶比较。
Int J Pharm. 2023 Nov 25;647:123494. doi: 10.1016/j.ijpharm.2023.123494. Epub 2023 Oct 6.
4
A Guide to Best Practice in Sensory Analysis of Pharmaceutical Formulations.药物制剂感官分析最佳实践指南。
Pharmaceutics. 2023 Sep 14;15(9):2319. doi: 10.3390/pharmaceutics15092319.
5
Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology.基于药效团模型、系统分离和苦味追踪技术的整合策略，发现和验证三七中的苦味成分。
Food Chem. 2023 Dec 1;428:136716. doi: 10.1016/j.foodchem.2023.136716. Epub 2023 Jun 27.
6
Identification of compounds that enhance bitterness of coffee brew.鉴定可增强咖啡冲泡液苦味的化合物。
Food Chem. 2023 Jul 30;415:135674. doi: 10.1016/j.foodchem.2023.135674. Epub 2023 Feb 15.
7
An Overview of Taste-Masking Technologies: Approaches, Application, and Assessment Methods.掩味技术概述：方法、应用和评估方法。
AAPS PharmSciTech. 2023 Feb 14;24(2):67. doi: 10.1208/s12249-023-02520-z.
8
Comparison of Bitterness Intensity between Prednisolone and Quinine in a Human Sensory Test Indicated Individual Differences in Bitter-Taste Perception.一项人体感官测试中泼尼松龙和奎宁苦味强度的比较表明苦味感知存在个体差异。
Pharmaceutics. 2022 Nov 14;14(11):2454. doi: 10.3390/pharmaceutics14112454.
9
Characterization of bitter peptides in casein hydrolysates using comprehensive two-dimensional liquid chromatography.利用全面二维液相色谱法对酪蛋白水解产物中的苦味肽进行表征。
Food Chem. 2023 Mar 15;404(Pt A):134527. doi: 10.1016/j.foodchem.2022.134527. Epub 2022 Oct 6.
10
Detection of Bitterness in Vitamins Is Mediated by the Activation of Bitter Taste Receptors.维生素的苦味检测是由苦味味觉受体的激活介导的。
Nutrients. 2022 Oct 5;14(19):4141. doi: 10.3390/nu14194141.