Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 451951159, Iran.
School of Engineering, Institute for Bioengineering, The University of Edinburgh, Edinburgh EH9 3JL, UK.
J Mater Chem B. 2024 Oct 2;12(38):9478-9507. doi: 10.1039/d4tb00841c.
Wound infections, marked by the proliferation of microorganisms at surgical sites, necessitate the development of innovative wound dressings with potent bactericidal properties to curb microbial growth and prevent bacterial infiltration. This study explores the recent strides in utilizing ionic liquid-based polymers as highly promising antimicrobial agents for advanced wound healing applications. Specifically, cationic polymers containing quaternary ammonium, imidazolium, guanidinium, pyridinium, triazolium, or phosphonium groups have emerged as exceptionally effective antimicrobial compounds. Their mechanism of action involves disrupting bacterial membranes, thereby preventing the development of resistance and minimizing toxicity to mammalian cells. This comprehensive review not only elucidates the intricate dynamics of the skin's immune response and the various stages of wound healing but also delves into the synthesis methodologies of ionic liquid-based polymers. By spotlighting the practical applications of antimicrobial wound dressings, particularly those incorporating ionic liquid-based materials, this review aims to lay the groundwork for future research endeavors in this burgeoning field. Through a nuanced examination of these advancements, this article seeks to contribute to the ongoing progress in developing cutting-edge wound healing platforms that can effectively address the challenges posed by microbial infections in surgical wounds.
伤口感染是指在手术部位微生物的大量繁殖，因此需要开发具有强大杀菌性能的新型伤口敷料来抑制微生物的生长和防止细菌渗透。本研究探讨了利用基于离子液体的聚合物作为高级伤口愈合应用中极有前途的抗菌剂的最新进展。具体来说，含有季铵盐、咪唑啉、胍、吡啶、三唑或鏻基团的阳离子聚合物已成为非常有效的抗菌化合物。它们的作用机制涉及破坏细菌膜，从而防止产生抗药性并最大程度地减少对哺乳动物细胞的毒性。这篇综述不仅阐明了皮肤免疫反应的复杂动态和伤口愈合的各个阶段，还深入探讨了基于离子液体的聚合物的合成方法。通过突出抗菌伤口敷料的实际应用，特别是那些包含基于离子液体的材料的应用，本综述旨在为这一新兴领域的未来研究工作奠定基础。通过对这些进展的细致研究，本文旨在为开发能够有效应对手术伤口中微生物感染所带来挑战的尖端伤口愈合平台做出贡献。
