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Eosinophilia with N642H Mutation: A Heterogeneous Entity with Overlapping Morphological Features and Poor Outcome.

作者信息

Shashidhar Venkat, Karthikeyan Aishwarya, Balakrishnan Anand, Raina Sudhanshi, Ahluwalia Jasmina, Das Reena, Malhotra Pankaj, Sreedharanunni Sreejesh

机构信息

Postgraduate Institute of Medical Education and Research, Department of Hematology, Chandigarh, India

Postgraduate Institute of Medical Education and Research, Department of Clinical Hematology and Medical Oncology, Chandigarh, India

出版信息

Turk J Haematol. 2024 Dec 2;41(4):275-278. doi: 10.4274/tjh.galenos.2024.2024.0204. Epub 2024 Aug 29.

DOI:10.4274/tjh.galenos.2024.2024.0204
PMID:39206794
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11628759/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c6f/11628759/a052915830da/TurkJHematol-41-275-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c6f/11628759/a052915830da/TurkJHematol-41-275-figure-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c6f/11628759/a052915830da/TurkJHematol-41-275-figure-1.jpg

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Eosinophilia with N642H Mutation: A Heterogeneous Entity with Overlapping Morphological Features and Poor Outcome.伴有N642H突变的嗜酸性粒细胞增多症：一种具有重叠形态学特征和不良预后的异质性实体。
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本文引用的文献

1
Anti-IL-5 Pathway Agents in Eosinophilic-Associated Disorders Across the Lifespan.抗白细胞介素-5 通路药物在全生命周期嗜酸粒细胞相关疾病中的应用。
Drugs. 2024 Jun;84(6):661-684. doi: 10.1007/s40265-024-02037-0. Epub 2024 Jun 8.
2
mutations in myeloid neoplasms differ by disease subtypes but characterize a subset of chronic myeloid neoplasms with eosinophilia and/or basophilia.髓系肿瘤的突变因疾病亚型而异，但特征是伴有嗜酸性粒细胞增多和/或嗜碱性粒细胞增多的慢性髓系肿瘤亚群的一部分。
Haematologica. 2024 Jun 1;109(6):1825-1835. doi: 10.3324/haematol.2023.284311.
3
STAT5b: A master regulator of key biological pathways.
STAT5b：关键生物途径的主调控因子。
Front Immunol. 2023 Jan 23;13:1025373. doi: 10.3389/fimmu.2022.1025373. eCollection 2022.
4
Activating mutations can cause both primary hypereosinophilia and lymphocyte-variant hypereosinophilia.激活突变可导致原发性嗜酸性粒细胞增多症和淋巴细胞变异型嗜酸性粒细胞增多症。
Leuk Lymphoma. 2023 Jan;64(1):238-241. doi: 10.1080/10428194.2022.2131413. Epub 2022 Oct 28.
5
Chronic eosinophilic leukemia with recurrent STAT5B N642H mutation-An entity with features of myelodysplastic syndrome/ myeloproliferative neoplasm overlap.伴有复发性STAT5B N642H突变的慢性嗜酸性粒细胞白血病——一种具有骨髓增生异常综合征/骨髓增殖性肿瘤重叠特征的实体。
Leuk Res. 2022 Jan;112:106753. doi: 10.1016/j.leukres.2021.106753. Epub 2021 Nov 23.
6
JAK inhibition in early-onset somatic, nonclonal STAT5B gain-of-function disease.早发性体细胞非克隆性STAT5B功能获得性疾病中的JAK抑制作用
J Allergy Clin Immunol Pract. 2021 Feb;9(2):1008-1010.e2. doi: 10.1016/j.jaip.2020.11.050. Epub 2020 Dec 5.
7
Eosinophilia Associated With CD3CD4 T Cells: Characterization and Outcome of a Single-Center Cohort of 26 Patients.伴有 CD3+CD4+T 细胞的嗜酸性粒细胞增多症：单中心 26 例患者队列的特征和转归。
Front Immunol. 2020 Aug 11;11:1765. doi: 10.3389/fimmu.2020.01765. eCollection 2020.
8
Structural and functional consequences of the STAT5B driver mutation.STAT5B 驱动突变的结构和功能后果。
Nat Commun. 2019 Jun 7;10(1):2517. doi: 10.1038/s41467-019-10422-7.
9
Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia.伴有嗜酸性粒细胞增多的髓系肿瘤中复发性激活 STAT5B N642H 突变。
Leukemia. 2019 Feb;33(2):415-425. doi: 10.1038/s41375-018-0342-3. Epub 2018 Dec 20.
10
Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes.德巴金（左乙拉西坦）作为一种口服类固醇激素节约剂，用于嗜酸性粒细胞增多综合征。
Blood. 2018 Aug 2;132(5):501-509. doi: 10.1182/blood-2018-02-835330. Epub 2018 May 8.