JAK inhibition in early-onset somatic, nonclonal STAT5B gain-of-function disease.
作者信息
Eisenberg Rachel, Gans Melissa D, Leahy Timothy Ronan, Gothe Florian, Perry Candice, Raffeld Mark, Xi Liqiang, Blackstone Sarah, Ma Chi, Hambleton Sophie, Milner Joshua D
机构信息
Albert Einstein College of Medicine, Children's Hospital at Montefiore Medical Center, Division of Allergy and Immunology, Bronx, NY.
Albert Einstein College of Medicine, Children's Hospital at Montefiore Medical Center, Division of Allergy and Immunology, Bronx, NY.
出版信息
J Allergy Clin Immunol Pract. 2021 Feb;9(2):1008-1010.e2. doi: 10.1016/j.jaip.2020.11.050. Epub 2020 Dec 5.
Abstract
摘要
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本文引用的文献
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Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia.伴有嗜酸性粒细胞增多的髓系肿瘤中复发性激活 STAT5B N642H 突变。
Leukemia. 2019 Feb;33(2):415-425. doi: 10.1038/s41375-018-0342-3. Epub 2018 Dec 20.
2
Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations.Jakinibs 治疗信号转导子和转录激活因子 1（STAT1）或 STAT3 基因突变致免疫失调患者。
J Allergy Clin Immunol. 2018 Nov;142(5):1665-1669. doi: 10.1016/j.jaci.2018.07.020. Epub 2018 Aug 6.
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JAK1 gain-of-function causes an autosomal dominant immune dysregulatory and hypereosinophilic syndrome.JAK1功能获得性突变导致常染色体显性遗传的免疫失调和嗜酸性粒细胞增多综合征。
J Allergy Clin Immunol. 2017 Jun;139(6):2016-2020.e5. doi: 10.1016/j.jaci.2016.12.957. Epub 2017 Jan 19.
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Pediatr Blood Cancer. 2015 Oct;62(10):1717-24. doi: 10.1002/pbc.25575. Epub 2015 May 13.
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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.激活型STAT5B N642H突变是儿童T细胞急性淋巴细胞白血病中的常见异常，会增加复发风险。
Haematologica. 2014 Oct;99(10):e188-92. doi: 10.3324/haematol.2014.104992. Epub 2014 Jun 27.
8
STAT transcription factors in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention.STAT 转录因子在造血和白血病发生中的作用：治疗干预的机会。
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Eur J Haematol. 2012 Oct;89(4):288-93. doi: 10.1111/j.1600-0609.2012.01825.x. Epub 2012 Jul 26.
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