Elisha Cherise, Bhagwat Prashant, Pillai Santhosh
Department of Biotechnology and Food Science, Faculty of Applied Sciences, Durban University of Technology, Durban, South Africa.
Crit Rev Food Sci Nutr. 2024 Aug 29:1-30. doi: 10.1080/10408398.2024.2396067.
Bioactive peptides (BPs) are short amino acid sequences that that are known to exhibit physiological characteristics such as antioxidant, antimicrobial, antihypertensive and antidiabetic properties, suggesting that they could be exploited as functional foods in the nutraceutical industry. These BPs can be derived from a variety of food sources, including milk, meat, marine, and plant proteins. In the past decade, various methods including in silico, in vitro, and in vivo techniques have been explored to unravel underlying mechanisms of BPs. To forecast interactions between peptides and their targets, in silico methods such as BIOPEP, molecular docking and Quantitative Structure-Activity Relationship modeling have been employed. Additionally, in vitro research has examined how BPs affect enzyme activities, protein expressions, and cell cultures. In vivo studies on the contrary have appraised the impact of BPs on animal models and human subjects. Hence, in the light of recent literature, this review examines the multifaceted aspects of BPs production from milk, meat, marine, and plant proteins and their potential bioactivities. We envisage that the various concepts discussed will contribute to a better understanding of the food derived BP production, which could pave a way for their potential applications in the nutraceutical industry.
生物活性肽（BPs）是短氨基酸序列，已知具有抗氧化、抗菌、抗高血压和抗糖尿病等生理特性，这表明它们可作为营养保健品行业的功能性食品加以利用。这些生物活性肽可来源于多种食物，包括牛奶、肉类、海产品和植物蛋白。在过去十年中，人们探索了多种方法，包括计算机模拟、体外和体内技术，以揭示生物活性肽的潜在机制。为预测肽与其靶点之间的相互作用，已采用了诸如BIOPEP、分子对接和定量构效关系建模等计算机模拟方法。此外，体外研究考察了生物活性肽如何影响酶活性、蛋白质表达和细胞培养。相反，体内研究评估了生物活性肽对动物模型和人类受试者的影响。因此，鉴于近期文献，本综述考察了从牛奶、肉类、海产品和植物蛋白中生产生物活性肽的多方面情况及其潜在生物活性。我们设想，所讨论的各种概念将有助于更好地理解源自食物的生物活性肽的生产，这可为其在营养保健品行业的潜在应用铺平道路。
