Hamdi Marwa, Kilari Bhanu Priya, Mudgil Priti, Nirmal Nilesh Prakash, Ojha Shreesh, Ayoub Mohammed Akli, Amin Amr, Maqsood Sajid
Food Science Department, College of Agriculture and Veterinary Medicine, United Arab Emirates University, Al-Ain, United Arab Emirates.
Institute of Nutrition, Mahidol University, Salaya, Nakhon Pathom, Thailand.
Crit Rev Biotechnol. 2025 Jan 5:1-22. doi: 10.1080/07388551.2024.2435965.
Recently, bioactive peptides, from natural resources, have attracted remarkable attention as nutraceutical treasures and the health benefits of their consumption have extensively been studied. Therapies based on bioactive peptides have been recognized as an innovative and promising alternative method for dangerous diseases such as cancer. Indeed, there has been enormous interest in nutraceuticals and bioactive-based chemopreventive molecules as a potential opportunity to manage chronic diseases, including cancer at different stages, rather than the traditionally used therapies. The relative safety and efficacy of these peptides in targeting only the tumor cells without affecting the normal cells make them attractive alternatives to existing pharmaceuticals for the treatment, management, and prevention of cancer, being able to act as potential physiological modulators of metabolism during their intestinal digestion. Novel bioactive peptides derived from food sources can be beneficial as anticancer nutraceuticals and provide a basis for the pharmaceutical development of food-derived bioactive peptides. Bioactive peptides can be generated through different protein hydrolysis methods and purified using advanced chromatographic techniques. Moreover, establishing bioactive peptides' efficacy and mechanism of action can provide alternative methods for cancer prevention and management. Most of the research on anticancer peptides is carried out on cell lines with very limited research being investigated in animal models or human clinical models. In this context, this review article comprehensively discusses anticancer peptides': production, isolation, therapeutic strategies, mechanism of action, and application in cancer therapy.
近年来，源自自然资源的生物活性肽作为营养保健品备受关注，其食用对健康的益处也得到了广泛研究。基于生物活性肽的疗法已被视为治疗癌症等危险疾病的一种创新且有前景的替代方法。事实上，营养保健品和基于生物活性物质的化学预防分子作为管理包括不同阶段癌症在内的慢性疾病的潜在机会，而非传统使用的疗法，已引发了极大的兴趣。这些肽仅靶向肿瘤细胞而不影响正常细胞的相对安全性和有效性，使其成为现有治疗、管理和预防癌症药物的有吸引力的替代品，并且在肠道消化过程中能够作为潜在的代谢生理调节剂发挥作用。源自食物来源的新型生物活性肽作为抗癌营养保健品可能有益，并为食品源生物活性肽的药物开发提供基础。生物活性肽可通过不同的蛋白质水解方法产生，并使用先进的色谱技术进行纯化。此外，确立生物活性肽的功效和作用机制可为癌症预防和管理提供替代方法。大多数关于抗癌肽的研究是在细胞系上进行的，在动物模型或人类临床模型中的研究非常有限。在此背景下，这篇综述文章全面讨论了抗癌肽的生产、分离、治疗策略、作用机制以及在癌症治疗中的应用。
