中国健康女性中 HPV 多重或单一感染及基因型分布的流行情况：系统评价。

The prevalence of multiple or single HPV infection and genotype distribution in healthy Chinese women: A systemic review.

机构信息

Department of Public Health and Preventive Medicine, Baotou Medical College, The Clinical Epidemiology of Research Center, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, People's Republic of China.

Department of Cancer Epidemiology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

出版信息

J Cancer Res Ther. 2024 Aug 1;20(4):1265-1273. doi: 10.4103/jcrt.jcrt_224_23. Epub 2024 Aug 29.

DOI:10.4103/jcrt.jcrt_224_23

PMID:39206989

Abstract

BACKGROUND

We analyzed the prevalence and genotype distribution of multiple- or single-type cervical human papillomavirus (HPV) infections in a population of women in mainland China.

METHODS

PubMed, MEDLINE, and Chinese databases (CNKI, VIP, and Wan Fang) were searched for studies on HPV prevalence and the examination of this relationship. All analyses were performed using STATA (version 12.0). Data from selected studies were extracted into tables, and all included studies were weighted and summarized.

RESULTS

Thirty studies were included. The prevalence of single types (10.4%) and multiple types (4.7%) primarily occurred in healthy Chinese women, in which the dominant single-type infection was HPV16 (1.6%), 52 (1.5%), 58 (1.0%), and 18 (0.5%), and the dominant type of multiple infection was HPV16 (0.7%), 52 (0.7%), 58 (0.6%), and 18 (0.3%). The prevalence in North and South China was 14.3%, in which the prevalence of the single type was 10.41% and 8.27%, and the prevalence of multiple types was 4.00% and 6.52%, respectively.

CONCLUSION

Mainland China exhibits unique type-specific single and multiple HPV infections. Overall single or multiple HPV prevalence varied across regions of China, whereas type-specific HPV differences were relatively small.

摘要

背景

我们分析了中国大陆女性人群中多种或单一型宫颈人乳头瘤病毒（HPV）感染的流行率和基因型分布。

方法

检索了 PubMed、MEDLINE 和中国数据库（CNKI、VIP 和万方）中关于 HPV 流行率及其关系的研究。所有分析均使用 STATA（版本 12.0）进行。将选定研究的数据提取到表格中，并对所有纳入研究进行加权和总结。

结果

共纳入 30 项研究。单一类型（10.4%）和多种类型（4.7%）的流行率主要发生在健康的中国女性中，其中主要的单一型感染是 HPV16（1.6%）、52（1.5%）、58（1.0%）和 18（0.5%），主要的多型感染是 HPV16（0.7%）、52（0.7%）、58（0.6%）和 18（0.3%）。北方和南方的流行率分别为 14.3%，其中单一型的流行率分别为 10.41%和 8.27%，多型的流行率分别为 4.00%和 6.52%。