Department of Radiology, Peking University Third Hospital, Beijing, China.
Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
J Cancer Res Ther. 2024 Aug 1;20(4):1306-1313. doi: 10.4103/jcrt.jcrt_517_24. Epub 2024 Aug 29.
The current study aimed to investigate the dynamic changes in brain glymphatic function during chemotherapy in breast cancer patients (BCP) and their correlation with cognitive function.
A total of 40 healthy female participants (control group) and 80 female BCP were included. Various cognitive assessment tools were used to evaluate cognitive function. Diffusion tensor imaging along the perivascular space was employed to measure brain glymphatic function.
Following chemotherapy, BCP exhibited a significant decline in various cognitive scores. After chemotherapy, the along the perivascular space index, a parameter indicating brain glymphatic function, was slightly higher than that at baseline and the control group levels and was correlated with cognitive scores.
This study unveiled a close relationship between the dynamic changes in brain glymphatic function after chemotherapy and cognitive function in BCP. Our findings contribute to a deeper understanding of the brain mechanisms underlying chemotherapy-related cognitive impairment and provide a theoretical basis for future interventions and treatments. In addition, they offer a new perspective for exploring the relationship between brain function and cognitive states.
本研究旨在探讨乳腺癌患者（BCP）化疗期间脑内糖质分解系功能的动态变化及其与认知功能的相关性。
共纳入 40 名健康女性参与者（对照组）和 80 名女性 BCP。采用各种认知评估工具评估认知功能。采用血管周围空间扩散张量成像测量脑糖质分解系功能。
化疗后，BCP 的各项认知评分均显著下降。化疗后，血管周围空间指数（反映脑糖质分解系功能的参数）略高于基线和对照组水平，与认知评分相关。
本研究揭示了化疗后脑糖质分解系功能的动态变化与 BCP 认知功能之间的密切关系。我们的研究结果有助于深入了解化疗相关性认知障碍的脑机制，并为未来的干预和治疗提供理论依据。此外，为探索脑功能与认知状态之间的关系提供了新视角。
