Thompson C, Checkley S A
Psychopharmacology (Berl). 1985;85(1):65-8. doi: 10.1007/BF00427324.
Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydriasis was unaffected by alaproclate, suggesting that it does not significantly inhibit the reuptake of noradrenaline. The pilocarpine-induced miosis and the phenylephrine-induced mydriasis were both enhanced after 1 week but not after 3 weeks of treatment. This suggests that alaproclate acutely increases the responsiveness of postsynaptic muscarinic and alpha 1 adrenoceptors.
九名抑郁症患者接受了阿普氯胺（一种选择性5-羟色胺摄取抑制剂）治疗，剂量为每日400毫克，为期3周。在治疗前、治疗1周后和治疗3周后连续几天测量对酪胺、去氧肾上腺素和毛果芸香碱滴眼液的瞳孔反应。酪胺引起的瞳孔散大不受阿普氯胺影响，这表明它不会显著抑制去甲肾上腺素的再摄取。毛果芸香碱引起的瞳孔缩小和去氧肾上腺素引起的瞳孔散大在治疗1周后均增强，但在治疗3周后未增强。这表明阿普氯胺可急性增加突触后毒蕈碱和α1肾上腺素能受体的反应性。
