Menkes D B, Kehne J H, Gallager D W, Aghajanian G K, Davis M
Life Sci. 1983 Jul 11;33(2):181-8. doi: 10.1016/0024-3205(83)90411-3.
Chronic but not acute administration (21 days) of desipramine (10 mg/kg), amitriptyline (10 mg/kg) or iprindole (5 mg/kg) enhanced the stimulatory effect of the alpha 1-adrenergic agonist phenylephrine on the acoustic startle reflex when phenylephrine was infused into the subarachnoid space of the spinal cord. Comparable supersensitivity to phenylephrine also occurred 1 week after selective depletion of norepinephrine in the spinal cord via intrathecal administration of 6-hydroxydopamine. Behavioral supersensitivity to phenylephrine was associated with an increase in the number of 3H-prazosin binding sites following denervation but not following chronic antidepressant treatments. The results indicate that chronic antidepressant treatments may enhance functional alpha 1-adrenergic transmission through mechanisms different than those following denervation.
当将去氧肾上腺素注入脊髓蛛网膜下腔时，给予地昔帕明（10毫克/千克）、阿米替林（10毫克/千克）或异吲哚酮（5毫克/千克）进行慢性（而非急性，为期21天）给药，可增强α1-肾上腺素能激动剂去氧肾上腺素对听觉惊吓反射的刺激作用。通过鞘内注射6-羟基多巴胺选择性耗尽脊髓中的去甲肾上腺素1周后，对去氧肾上腺素也出现了类似的超敏反应。对去氧肾上腺素的行为超敏反应与去神经支配后3H-哌唑嗪结合位点数量的增加有关，但与慢性抗抑郁药治疗后无关。结果表明，慢性抗抑郁药治疗可能通过与去神经支配不同的机制增强功能性α1-肾上腺素能传递。
