Thrombosis, brain metastasis formation, and the perivascular metastatic niche-Novel insights from the tumor microvascular circulation.
作者信息
Alvarez-Breckenridge Christopher, Brastianos Priscilla K, Cahill Daniel P
机构信息
Department of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Neuro Oncol. 2024 Nov 4;26(11):2100-2101. doi: 10.1093/neuonc/noae168.
Abstract
摘要
相似文献
1
Thrombosis, brain metastasis formation, and the perivascular metastatic niche-Novel insights from the tumor microvascular circulation.血栓形成、脑转移瘤形成与血管周围转移微环境——肿瘤微血管循环的新见解
Neuro Oncol. 2024 Nov 4;26(11):2100-2101. doi: 10.1093/neuonc/noae168.
2
Pre-metastatic niche: formation, characteristics and therapeutic implication.转移前生态位：形成、特征及治疗意义
Signal Transduct Target Ther. 2024 Sep 25;9(1):236. doi: 10.1038/s41392-024-01937-7.
3
Breast Cancer-Secreted Factors Promote Lung Metastasis by Signaling Systemically to Induce a Fibrotic Premetastatic Niche.乳腺癌分泌因子通过全身性信号诱导纤维化前转移龛促进肺转移。
Cancer Res. 2023 Oct 13;83(20):3354-3367. doi: 10.1158/0008-5472.CAN-22-3707.
4
Single-cell RNA-sequencing identifies anti-cancer immune phenotypes in the early lung metastatic niche during breast cancer.单细胞 RNA 测序鉴定乳腺癌早期肺转移灶中的抗肿瘤免疫表型。
Clin Exp Metastasis. 2022 Dec;39(6):865-881. doi: 10.1007/s10585-022-10185-4. Epub 2022 Aug 24.
5
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2.来自肺促血栓形成微环境的细胞外囊泡通过整合素β2驱动癌症相关的血栓形成和转移。
Cell. 2025 Mar 20;188(6):1642-1661.e24. doi: 10.1016/j.cell.2025.01.025. Epub 2025 Feb 11.
6
Subtherapeutic Dose of Ionizing Radiation Reprograms the Pre-Metastatic Lung Niche, Accelerating Its Formation and Promoting Metastasis.亚治疗剂量的电离辐射可重编程肺转移前生态位，加速其形成并促进转移。
Int J Mol Sci. 2025 Jun 26;26(13):6145. doi: 10.3390/ijms26136145.
7
Small extracellular vesicles and particles (sEVPs) derived from tumor-free pre-metastatic organs promote breast cancer metastasis and support organotropism.源自无肿瘤转移前器官的小细胞外囊泡和颗粒（sEVPs）促进乳腺癌转移并支持器官趋向性。
Mol Cancer. 2025 Mar 8;24(1):72. doi: 10.1186/s12943-025-02235-8.
8
KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis.KLF4依赖的血管周围细胞可塑性介导转移前生态位的形成和转移。
Nat Med. 2017 Oct;23(10):1176-1190. doi: 10.1038/nm.4400. Epub 2017 Sep 18.
9
Brain infiltration of breast cancer stem cells is facilitated by paracrine signaling by inhibitor of differentiation 3 to nuclear respiratory factor 1.乳腺癌干细胞的脑浸润是由分化抑制因子 3 对核呼吸因子 1 的旁分泌信号促进的。
J Cancer Res Clin Oncol. 2022 Oct;148(10):2881-2891. doi: 10.1007/s00432-022-04026-w. Epub 2022 Jun 9.
10
Extracellular vesicles from a model of melanoma cancer-associated fibroblasts induce changes in brain microvascular cells consistent with pre-metastatic niche priming.来自黑色素瘤癌相关成纤维细胞模型的细胞外囊泡可诱导脑微血管细胞发生变化，这与转移前生态位启动一致。
bioRxiv. 2025 May 10:2025.05.09.651827. doi: 10.1101/2025.05.09.651827.
本文引用的文献
1
Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis.脑血液微循环紊乱和缺氧缺血微环境与脑转移的发展有关。
Neuro Oncol. 2024 Nov 4;26(11):2084-2099. doi: 10.1093/neuonc/noae094.
2
Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke.神经血管单元分析揭示骨桥蛋白对急性缺血性脑卒中血脑屏障的有害作用。
Acta Neuropathol. 2022 Aug;144(2):305-337. doi: 10.1007/s00401-022-02452-1. Epub 2022 Jun 25.
3
Tumor Immune Microenvironment of Brain Metastases: Toward Unlocking Antitumor Immunity.脑转移瘤的肿瘤免疫微环境：迈向释放抗肿瘤免疫力
Cancer Discov. 2022 May 2;12(5):1199-1216. doi: 10.1158/2159-8290.CD-21-0976.
4
Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells.尼达尼布和一种双特异性抗血管内皮生长因子/血管生成素2纳米抗体可选择性预防肺腺癌细胞的脑转移。
Clin Exp Metastasis. 2020 Dec;37(6):637-648. doi: 10.1007/s10585-020-10055-x. Epub 2020 Sep 12.
5
Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells.血流动力调节循环肿瘤细胞的捕获、黏附和外渗。
Dev Cell. 2018 Apr 9;45(1):33-52.e12. doi: 10.1016/j.devcel.2018.02.015.
6
Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain.血管生成素-2 介导血脑屏障损伤和三阴性乳腺癌细胞在脑内的定植。
J Pathol. 2014 Feb;232(3):369-81. doi: 10.1002/path.4304.
7
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.靶向 ANG2/TIE2 轴通过抑制血管生成和使促血管生成的髓样细胞的反弹失活来抑制肿瘤生长和转移。
Cancer Cell. 2011 Apr 12;19(4):512-26. doi: 10.1016/j.ccr.2011.02.005.
8
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth.血管生成素-2 和 VEGF 抑制剂对肿瘤血管生成和生长的协同作用。
Cancer Res. 2010 Mar 15;70(6):2213-23. doi: 10.1158/0008-5472.CAN-09-1977. Epub 2010 Mar 2.
9
Vascular endothelial growth factor modulates the transendothelial migration of MDA-MB-231 breast cancer cells through regulation of brain microvascular endothelial cell permeability.血管内皮生长因子通过调节脑微血管内皮细胞通透性来调控MDA-MB-231乳腺癌细胞的跨内皮迁移。
J Biol Chem. 2003 Feb 14;278(7):5277-84. doi: 10.1074/jbc.M210063200. Epub 2002 Nov 20.
Zotero 插件