Wang Jing, Xiang Chaowei, Luo Fang, Zeng Linghui, Zhang Chong, Zhang Jiankang, Zhu Huajian, He Ruoyu, Shao Jiaan
Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, Zhejiang 310015, People's Republic of China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, People's Republic of China.
Org Lett. 2024 Sep 13;26(36):7525-7529. doi: 10.1021/acs.orglett.4c02388. Epub 2024 Aug 29.
1,1,3-Polyfunctionalized cyclobutane derivatives have been synthesized from sulfur ylides and bicyclo[1.1.0]butanes (BCBs). This protocol operates under mild reaction conditions without the need for catalysts, generally producing moderate to good yields of -addition derivatives with structural diversity. An unexpected intramolecular rearrangement mechanism has also been proposed.
已通过硫叶立德和双环[1.1.0]丁烷（BCB）合成了1,1,3-多官能化环丁烷衍生物。该方法在温和的反应条件下进行，无需催化剂，通常能以中等至良好的产率生成具有结构多样性的加成衍生物。还提出了一种意想不到的分子内重排机制。
