Xiang Chaowei, Luo Fang, Wang Zheng, Pan Yunlong, Liu Yu, Zeng Linghui, Zhang Chong, Zhu Huajian, Zhang Jiankang, Shao Jiaan
Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou 310015, P. R. China.
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
J Org Chem. 2024 Jun 21;89(12):8878-8887. doi: 10.1021/acs.joc.4c00738. Epub 2024 Jun 7.
A one-pot approach has been developed for the synthesis of α-ketothioamide derivatives from sulfur ylides, nitrosobenzenes, and thioacetic acid. This protocol is carried out under mild reaction conditions in generally moderate to excellent yields without any precious catalysts, affording the derivatives with structural diversity. Additionally, a possible mechanism for this chemical transformation is proposed.
已开发出一种一锅法，用于从硫叶立德、亚硝基苯和硫代乙酸合成α-酮硫代酰胺衍生物。该方法在温和的反应条件下进行，产率一般为中等至优异，无需任何贵金属催化剂，可提供结构多样的衍生物。此外，还提出了这种化学转化的可能机理。
