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恩赛特韦治疗 COVID-19 奥密克戎变异株导致的医护人员咳嗽的疗效。

Efficacy of ensitrelvir for cough due to COVID-19 Omicron variant in medical healthcare workers.

机构信息

First Department of Internal Medicine, Division of Respiratory Medicine, Infectious Disease and Allergology, Kansai Medical University, Hirakata, Japan.

Department of Emergency Medicine, Kansai Medical University Medical Center, Moriguchi, Japan.

出版信息

Antimicrob Agents Chemother. 2024 Oct 8;68(10):e0106424. doi: 10.1128/aac.01064-24. Epub 2024 Aug 29.

DOI:10.1128/aac.01064-24
PMID:39207153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11459974/
Abstract

We evaluated the efficacy of ensitrelvir for the treatment of cough due to coronavirus disease 2019 Omicron variant in medical healthcare workers. A total of 633 patients were registered in this study: 206 patients chose ensitrelvir and 427 patients chose symptomatic treatment. Difference in score changes using the Leicester Cough Questionnaire between groups was 3.17 on day 4, 3.24 on day 7, and 2.46 on day 14. The analysis demonstrated a significant difference at all time points.

摘要

我们评估了恩赛特韦在治疗因新冠病毒奥密克戎变异株感染而引起的咳嗽方面的疗效。共有 633 名医护人员参与了这项研究:206 名患者选择了恩赛特韦,427 名患者选择了对症治疗。莱斯特咳嗽问卷评分的组间变化差异在第 4 天为 3.17,第 7 天为 3.24,第 14 天为 2.46。分析表明所有时间点均存在显著差异。

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Microbiol Spectr. 2025 Apr 15;13(5):e0340724. doi: 10.1128/spectrum.03407-24.

本文引用的文献

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Efficacy and Safety of 5-Day Oral Ensitrelvir for Patients With Mild to Moderate COVID-19: The SCORPIO-SR Randomized Clinical Trial.口服恩赛特韦 5 天治疗轻中度 COVID-19 患者的疗效和安全性:SCORPIO-SR 随机临床试验。
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Associations of COVID-19 symptoms with omicron subvariants BA.2 and BA.5, host status, and clinical outcomes in Japan: a registry-based observational study.日本基于登记的观察性研究:COVID-19 症状与奥密克戎亚变体 BA.2 和 BA.5、宿主状态和临床结局的关联。
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Efficacy and Safety of Ensitrelvir in Patients With Mild-to-Moderate Coronavirus Disease 2019: The Phase 2b Part of a Randomized, Placebo-Controlled, Phase 2/3 Study.恩赛特韦在轻至中度 2019 冠状病毒病患者中的疗效和安全性:一项随机、安慰剂对照、2/3 期研究的 2b 期部分。
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A Randomized Phase 2/3 Study of Ensitrelvir, a Novel Oral SARS-CoV-2 3C-Like Protease Inhibitor, in Japanese Patients with Mild-to-Moderate COVID-19 or Asymptomatic SARS-CoV-2 Infection: Results of the Phase 2a Part.一项评估新型口服 SARS-CoV-2 3CL 蛋白酶抑制剂恩赛特韦(ensitrelvir)在日本轻至中度 COVID-19 或无症状 SARS-CoV-2 感染患者中的疗效和安全性的随机 2/3 期研究:2a 期部分结果。
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5
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