Kangda College of Nanjing Medical University, Lianyungang 222000, Jiangsu, China.
Department of Laboratory Medicine, Tianjin Peace District Obstetrics and Gynecology Hospital, Tianjin, 300020, China.
Anal Methods. 2024 Sep 19;16(36):6134-6155. doi: 10.1039/d4ay01307g.
Considerable progress has been made in the electrochemical determination of acetaminophen (AP) over the past few decades. Nanomaterials or enzymes as electrode modifiers greatly improve the performance of AP electrochemical sensors. This review focuses on the development potential, detection principles and techniques for the electrochemical analysis of AP. In particular, the design and construction of AP electrochemical sensors are discussed from the perspective of non-enzyme materials (such as nanomaterials, including precious metals, transition metals and non-metals) and enzyme substances (such as aryl acylamidase, polyphenol oxidase and horseradish peroxidase). Moreover, the influencing factors for AP electrochemical sensors and the simultaneous detection of AP and other targets are summarized, and the future prospective of AP electrochemical sensors is outlined. This review provides a reference and guidance for the development and application of electrochemical sensors for AP detection.
在过去的几十年中，在乙酰氨基酚（AP）的电化学测定方面取得了相当大的进展。纳米材料或酶作为电极修饰剂极大地提高了 AP 电化学传感器的性能。本综述重点介绍了 AP 电化学分析的发展潜力、检测原理和技术。特别是，从非酶材料（如纳米材料，包括贵金属、过渡金属和非金属）和酶物质（如芳基酰氨酶、多酚氧化酶和辣根过氧化物酶）的角度讨论了 AP 电化学传感器的设计和构建。此外，总结了 AP 电化学传感器的影响因素以及 AP 和其他目标的同时检测，并概述了 AP 电化学传感器的未来前景。本综述为 AP 检测电化学传感器的开发和应用提供了参考和指导。
