Gu Jianxia, Fan Li, Bai Jian, Jin Zhanbin, Wei Tingting
Department of Chemistry, Xinzhou Normal University, Xinzhou, China.
Anal Bioanal Chem. 2025 May 10. doi: 10.1007/s00216-025-05901-4.
Electrochemical sensors for acetaminophen (AP) determination often face limitations in linear range, rarely achieving millimolar levels. This work synthesized CoNi-LDH (cobalt-nickel layered double hydroxide) via a simple hydrothermal method. By optimizing the Co/Ni ratio, the sensor based on CoNi-LDH-1 demonstrates efficient AP detection with an ultra-wide linear range spanning from 5 μM to 5 mM, enabling versatile AP monitoring in diverse samples. Furthermore, the sensor also exhibits exceptional stability, reproducibility, and selectivity. Notably, it successfully quantified AP in real-world samples (tap water and urine) while maintaining a wide linear range. The superior performance of the sensor stems from CoNi-LDH-1's unique spiky sphere morphology, abundant active sites, enhanced electron transport capability, and the synergistic effect between Co and Ni components. This work provides valuable insights for expanding the linear range of electrochemical sensors, advancing their application in analytical chemistry.
用于对乙酰氨基酚（AP）测定的电化学传感器在线性范围方面常常面临限制，很少能达到毫摩尔水平。本工作通过一种简单的水热法合成了CoNi-LDH（钴镍层状双氢氧化物）。通过优化Co/Ni比例，基于CoNi-LDH-1的传感器展示了高效的AP检测能力，其超宽线性范围从5 μM到5 mM，能够在各种样品中对AP进行通用监测。此外，该传感器还表现出卓越的稳定性、重现性和选择性。值得注意的是，它在保持宽线性范围的同时成功对实际样品（自来水和尿液）中的AP进行了定量。该传感器的优异性能源于CoNi-LDH-1独特的尖刺球状形态、丰富的活性位点、增强的电子传输能力以及Co和Ni组分之间的协同效应。这项工作为扩展电化学传感器的线性范围、推动其在分析化学中的应用提供了有价值的见解。
